7z26: Difference between revisions

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OCA

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-'''Unreleased structure'''
-The entry 7z26 is ON HOLD
+==Crystal structure of YTHDF2 YTH domain in complex with m6A RNA==
+<StructureSection load='7z26' size='340' side='right'caption='[[7z26]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-Authors: Nai, F., Nachawati, R., Li, Y., Caflisch, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7z26]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Z26 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Z26 FirstGlance]. <br>
-Description: Crystal structure of YTHDF2 YTH domain in complex with m6A RNA
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Nai, F]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7z26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7z26 OCA], [https://pdbe.org/7z26 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7z26 RCSB], [https://www.ebi.ac.uk/pdbsum/7z26 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7z26 ProSAT]</span></td></tr>
-[[Category: Li, Y]]
+</table>
-[[Category: Nachawati, R]]
+== Function ==
-[[Category: Caflisch, A]]
+[https://www.uniprot.org/uniprot/YTHD2_HUMAN YTHD2_HUMAN] Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization of to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation.<ref>PMID:22575960</ref> <ref>PMID:24284625</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Caflisch A]]
+[[Category: Li Y]]
+[[Category: Nachawati R]]
+[[Category: Nai F]]