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==Cryo-EM structure of corticotropin releasing factor receptor 2 bound to Urocortin 1 and coupled with heterotrimeric Go protein== | |||
<StructureSection load='7ts0' size='340' side='right'caption='[[7ts0]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7ts0]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TS0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TS0 FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ts0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ts0 OCA], [https://pdbe.org/7ts0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ts0 RCSB], [https://www.ebi.ac.uk/pdbsum/7ts0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ts0 ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/CRFR2_HUMAN CRFR2_HUMAN] G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. | ||
[[Category: | __TOC__ | ||
[[Category: Lin | </StructureSection> | ||
[[Category: Melcher | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Rattus norvegicus]] | ||
[[Category: | [[Category: Synthetic construct]] | ||
[[Category: | [[Category: Ji S]] | ||
[[Category: | [[Category: Lin J]] | ||
[[Category: | [[Category: Mao C]] | ||
[[Category: Melcher K]] | |||
[[Category: Shen D]] | |||
[[Category: Xiao P]] | |||
[[Category: Xu HE]] | |||
[[Category: Yu X]] | |||
[[Category: Zhang Y]] | |||
[[Category: Zhao L-H]] | |||
[[Category: Zhou XE]] | |||
Latest revision as of 10:22, 9 November 2022
Cryo-EM structure of corticotropin releasing factor receptor 2 bound to Urocortin 1 and coupled with heterotrimeric Go proteinCryo-EM structure of corticotropin releasing factor receptor 2 bound to Urocortin 1 and coupled with heterotrimeric Go protein
Structural highlights
FunctionCRFR2_HUMAN G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. |
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