Akt/PKB signaling pathway: Difference between revisions
No edit summary |
No edit summary |
||
| (One intermediate revision by the same user not shown) | |||
| Line 15: | Line 15: | ||
*[[Phosphoinositide 3-Kinases]] | *[[Phosphoinositide 3-Kinases]] | ||
*[[PI3K Activation, Inhibition, & Medical Implications]] | *[[PI3K Activation, Inhibition, & Medical Implications]] | ||
PI3K can also be activated by [[G protein-coupled receptors]] (GPCRs), via G-protein βγ dimers or Ras which bind PI3K directly. In addition, the Gα subunit activates Src-dependent integrin signaling which can activate PI3K. | |||
==Phosphoinositide formation== | |||
The triphosphate form (PI(3,4,5)P3) binds Akt and [[phosphoinositide-dependent kinase 1]] (PDK1) so they accumulate in close proximity at the membrane. | |||
=Akt/PKB= | =Akt/PKB= | ||