3fw9: Difference between revisions
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<StructureSection load='3fw9' size='340' side='right'caption='[[3fw9]], [[Resolution|resolution]] 1.49Å' scene=''> | <StructureSection load='3fw9' size='340' side='right'caption='[[3fw9]], [[Resolution|resolution]] 1.49Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3fw9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3fw9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Eschscholzia_californica Eschscholzia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FW9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FW9 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SLX:(13AS)-3,10-DIMETHOXY-5,8,13,13A-TETRAHYDRO-6H-ISOQUINO[3,2-A]ISOQUINOLINE-2,9-DIOL'>SLX</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.489Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SLX:(13AS)-3,10-DIMETHOXY-5,8,13,13A-TETRAHYDRO-6H-ISOQUINO[3,2-A]ISOQUINOLINE-2,9-DIOL'>SLX</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fw9 OCA], [https://pdbe.org/3fw9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fw9 RCSB], [https://www.ebi.ac.uk/pdbsum/3fw9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fw9 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fw9 OCA], [https://pdbe.org/3fw9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fw9 RCSB], [https://www.ebi.ac.uk/pdbsum/3fw9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fw9 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/RETO_ESCCA RETO_ESCCA] Essential to the formation of benzophenanthridine alkaloids in the response of plants to pathogenic attack. Catalyzes the stereospecific conversion of the N-methyl moiety of (S)-reticuline into the berberine bridge carbon of (S)-scoulerine. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Eschscholzia californica]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Gruber K]] | |||
[[Category: Gruber | [[Category: Macheroux P]] | ||
[[Category: Macheroux | [[Category: Winkler A]] | ||
[[Category: Winkler | |||
Latest revision as of 09:53, 6 September 2023
Structure of berberine bridge enzyme in complex with (S)-scoulerineStructure of berberine bridge enzyme in complex with (S)-scoulerine
Structural highlights
FunctionRETO_ESCCA Essential to the formation of benzophenanthridine alkaloids in the response of plants to pathogenic attack. Catalyzes the stereospecific conversion of the N-methyl moiety of (S)-reticuline into the berberine bridge carbon of (S)-scoulerine. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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