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==Structure of the transmembrane domain of human nicastrin in SDS micelles==
==Structure of the transmembrane domain of human nicastrin in SDS micelles==
<StructureSection load='2n7q' size='340' side='right'caption='[[2n7q]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2n7q' size='340' side='right'caption='[[2n7q]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2n7q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N7Q FirstGlance]. <br>
<table><tr><td colspan='2'>[[2n7q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N7Q FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2n7r|2n7r]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n7q OCA], [https://pdbe.org/2n7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n7q RCSB], [https://www.ebi.ac.uk/pdbsum/2n7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n7q ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n7q OCA], [https://pdbe.org/2n7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n7q RCSB], [https://www.ebi.ac.uk/pdbsum/2n7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n7q ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[https://www.uniprot.org/uniprot/NICA_HUMAN NICA_HUMAN]] Hidradenitis suppurativa. The disease is caused by mutations affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/NICA_HUMAN NICA_HUMAN] Hidradenitis suppurativa. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/NICA_HUMAN NICA_HUMAN]] Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.  
[https://www.uniprot.org/uniprot/NICA_HUMAN NICA_HUMAN] Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Nicastrin is the largest component of gamma-secretase that is an intramembrane protease important in the development of Alzheimer's disease. Nicastrin contains a large extracellular domain, a single transmembrane (TM) domain, and a short C-terminus. Its TM domain is important for the gamma-secretase complex formation. Here we report nuclear magnetic resonance (NMR) studies of the TM and C-terminal regions of human nicastrin in both sodium dodecyl sulfate (SDS) and dodecylphosphocholine (DPC) micelles. Structural study and dynamic analysis reveal that the TM domain is largely helical and stable under both SDS and DPC micelles with its N-terminal region undergoing intermediate time scale motion. The TM helix contains a hydrophilic patch that is important for TM-TM interactions. The short C-terminus is not structured in solution and a region formed by residues V697-A702 interacts with the membrane, suggesting that these residues may play a role in the gamma-secretase complex formation. Our study provides structural insight into the function of the nicastrin TM domain and the C-terminus in gamma-secretase complex.
 
Structure of the transmembrane domain of human nicastrin-a component of gamma-secretase.,Li Y, Liew LS, Li Q, Kang C Sci Rep. 2016 Jan 18;6:19522. doi: 10.1038/srep19522. PMID:26776682<ref>PMID:26776682</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2n7q" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Gamma secretase|Gamma secretase]]
*[[Gamma secretase|Gamma secretase]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Kang, C]]
[[Category: Kang C]]
[[Category: Li, Q]]
[[Category: Li Q]]
[[Category: Li, Y]]
[[Category: Li Y]]
[[Category: Liew, L]]
[[Category: Liew L]]
[[Category: Detergent micelle]]
[[Category: Gamma-secretase]]
[[Category: Membrane protein]]
[[Category: Nicastrin]]

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