1fyj: Difference between revisions
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==SOLUTION STRUCTURE OF MULTI-FUNCTIONAL PEPTIDE MOTIF-1 PRESENT IN HUMAN GLUTAMYL-PROLYL TRNA SYNTHETASE (EPRS).== | ==SOLUTION STRUCTURE OF MULTI-FUNCTIONAL PEPTIDE MOTIF-1 PRESENT IN HUMAN GLUTAMYL-PROLYL TRNA SYNTHETASE (EPRS).== | ||
<StructureSection load='1fyj' size='340' side='right'caption='[[1fyj | <StructureSection load='1fyj' size='340' side='right'caption='[[1fyj]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1fyj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1fyj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FYJ FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fyj OCA], [https://pdbe.org/1fyj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fyj RCSB], [https://www.ebi.ac.uk/pdbsum/1fyj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fyj ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fyj OCA], [https://pdbe.org/1fyj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fyj RCSB], [https://www.ebi.ac.uk/pdbsum/1fyj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fyj ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/SYEP_HUMAN SYEP_HUMAN] Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the multisynthetase complex and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.<ref>PMID:1756734</ref> <ref>PMID:15479637</ref> <ref>PMID:23071094</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Hwang | [[Category: Hwang G-S]] | ||
[[Category: Jeong | [[Category: Jeong E-J]] | ||
[[Category: Kim | [[Category: Kim K-S]] | ||
[[Category: Kim | [[Category: Kim KH]] | ||
[[Category: Kim | [[Category: Kim MJ]] | ||
[[Category: Kim | [[Category: Kim S]] | ||