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==THREE-DIMENSIONAL STRUCTURE OF THE PENTAMERIC HELICAL BUNDLE OF THE ACETYLCHOLINE RECEPTOR M2 TRANSMEMBRANE SEGMENT==
==THREE-DIMENSIONAL STRUCTURE OF THE PENTAMERIC HELICAL BUNDLE OF THE ACETYLCHOLINE RECEPTOR M2 TRANSMEMBRANE SEGMENT==
<StructureSection load='1eq8' size='340' side='right'caption='[[1eq8]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
<StructureSection load='1eq8' size='340' side='right'caption='[[1eq8]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1eq8]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Pacific_electric_ray Pacific electric ray]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EQ8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1eq8]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetronarce_californica Tetronarce californica]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EQ8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solid-state NMR, 1 model</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1a11|1a11]], [[1cek|1cek]]</div></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1eq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eq8 OCA], [https://pdbe.org/1eq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1eq8 RCSB], [https://www.ebi.ac.uk/pdbsum/1eq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1eq8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1eq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eq8 OCA], [https://pdbe.org/1eq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1eq8 RCSB], [https://www.ebi.ac.uk/pdbsum/1eq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1eq8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/ACHD_TORCA ACHD_TORCA]] After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.  
[https://www.uniprot.org/uniprot/ACHD_TETCF ACHD_TETCF] After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Pacific electric ray]]
[[Category: Tetronarce californica]]
[[Category: Gesell, J J]]
[[Category: Gesell JJ]]
[[Category: Kim, Y]]
[[Category: Kim Y]]
[[Category: Marassi, F M]]
[[Category: Marassi FM]]
[[Category: Montal, M]]
[[Category: Montal M]]
[[Category: Oblatt-Montal, M]]
[[Category: Oblatt-Montal M]]
[[Category: Opella, S J]]
[[Category: Opella SJ]]
[[Category: Valente, A P]]
[[Category: Valente AP]]
[[Category: Helical bundle]]
[[Category: Ion-channel]]
[[Category: Lipid bilayer]]
[[Category: M2]]
[[Category: Neurotransmitter receptor]]
[[Category: Pentameric bundle]]
[[Category: Signaling protein]]

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