3e07: Difference between revisions
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<StructureSection load='3e07' size='340' side='right'caption='[[3e07]], [[Resolution|resolution]] 2.40Å' scene=''> | <StructureSection load='3e07' size='340' side='right'caption='[[3e07]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3e07]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3e07]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E07 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E07 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e07 OCA], [https://pdbe.org/3e07 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e07 RCSB], [https://www.ebi.ac.uk/pdbsum/3e07 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e07 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e07 OCA], [https://pdbe.org/3e07 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e07 RCSB], [https://www.ebi.ac.uk/pdbsum/3e07 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e07 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/SPZ_DROME SPZ_DROME] Component of the extracellular signaling pathway that establishes the dorsal-ventral pathway of the embryo. Three proteases; ndl, gd and snk process easter to create active easter. Active easter defines cell identities along the dorsal-ventral continuum by activating the spz ligand for the Tl receptor in the ventral region of the embryo. Spz C-106 in the hemolymph controls expression of the antifungal peptide Drosomycin (Drs) by acting as a ligand of Tl and inducing an intracellular signaling pathway.<ref>PMID:8124709</ref> <ref>PMID:11212919</ref> <ref>PMID:8808632</ref> <ref>PMID:12872120</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Drosophila melanogaster]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Balbach | [[Category: Balbach J]] | ||
[[Category: Funkner | [[Category: Funkner A]] | ||
[[Category: Hoffmann | [[Category: Hoffmann A]] | ||
[[Category: Juhnke | [[Category: Juhnke S]] | ||
[[Category: Neumann | [[Category: Neumann P]] | ||
[[Category: Reuter | [[Category: Reuter G]] | ||
[[Category: Schierhorn | [[Category: Schierhorn A]] | ||
[[Category: Stubbs | [[Category: Stubbs MT]] | ||
[[Category: Walther | [[Category: Walther M]] | ||
[[Category: Weininger | [[Category: Weininger U]] | ||