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<StructureSection load='3dxr' size='340' side='right'caption='[[3dxr]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='3dxr' size='340' side='right'caption='[[3dxr]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3dxr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DXR FirstGlance]. <br>
<table><tr><td colspan='2'>[[3dxr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DXR FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2bsk|2bsk]], [[3cjh|3cjh]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TIM9 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824]), MRS11, TIM10 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dxr OCA], [https://pdbe.org/3dxr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dxr RCSB], [https://www.ebi.ac.uk/pdbsum/3dxr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dxr ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dxr OCA], [https://pdbe.org/3dxr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dxr RCSB], [https://www.ebi.ac.uk/pdbsum/3dxr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dxr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/TIM9_YEAST TIM9_YEAST]] Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. Compared to TIM10, it may have a strong structural role.<ref>PMID:10369662</ref> <ref>PMID:10995434</ref> <ref>PMID:11483513</ref> <ref>PMID:11509656</ref> <ref>PMID:12138093</ref> <ref>PMID:12391147</ref> <ref>PMID:14978039</ref> <ref>PMID:16039669</ref> <ref>PMID:9822593</ref> <ref>PMID:9889188</ref> [[https://www.uniprot.org/uniprot/TIM10_YEAST TIM10_YEAST]] Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. Compared to TIM9, it may function as a substrate sensor.<ref>PMID:10369662</ref> <ref>PMID:10995434</ref> <ref>PMID:11483513</ref> <ref>PMID:11509656</ref> <ref>PMID:12138093</ref> <ref>PMID:12391147</ref> <ref>PMID:12637749</ref> <ref>PMID:14978039</ref> <ref>PMID:16039669</ref> <ref>PMID:8955274</ref> <ref>PMID:9430585</ref> <ref>PMID:9822593</ref> <ref>PMID:9889188</ref> 
[https://www.uniprot.org/uniprot/TIM9_YEAST TIM9_YEAST] Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. Compared to TIM10, it may have a strong structural role.<ref>PMID:10369662</ref> <ref>PMID:10995434</ref> <ref>PMID:11483513</ref> <ref>PMID:11509656</ref> <ref>PMID:12138093</ref> <ref>PMID:12391147</ref> <ref>PMID:14978039</ref> <ref>PMID:16039669</ref> <ref>PMID:9822593</ref> <ref>PMID:9889188</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Atcc 18824]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Gulbis, J M]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Webb, C T]]
[[Category: Gulbis JM]]
[[Category: Alpha-propeller]]
[[Category: Webb CT]]
[[Category: Chaperone]]
[[Category: Helix-turn-helix]]
[[Category: Inner membrane]]
[[Category: Intramolecular disulfides]]
[[Category: Membrane]]
[[Category: Metal-binding]]
[[Category: Mitochondrion]]
[[Category: Protein transport]]
[[Category: Translocation]]
[[Category: Transport]]
[[Category: Zinc]]

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