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==The Crystal Structure of human MYST1 from Biortus.==
==The Crystal Structure of human MYST1 from Wuxi Biortus.==
<StructureSection load='7cmr' size='340' side='right'caption='[[7cmr]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='7cmr' size='340' side='right'caption='[[7cmr]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7cmr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CMR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CMR FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CMR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CMR FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KAT8, MOF, MYST1, PP7073 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cmr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cmr OCA], [https://pdbe.org/7cmr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cmr RCSB], [https://www.ebi.ac.uk/pdbsum/7cmr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cmr ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cmr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cmr OCA], [https://pdbe.org/7cmr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cmr RCSB], [https://www.ebi.ac.uk/pdbsum/7cmr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cmr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/KAT8_HUMAN KAT8_HUMAN]] Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex.<ref>PMID:12397079</ref> <ref>PMID:15923642</ref> <ref>PMID:20018852</ref> 


==See Also==
==See Also==
*[[Histone acetyltransferase 3D structures|Histone acetyltransferase 3D structures]]
*[[Histone acetyltransferase 3D structures|Histone acetyltransferase 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Histone acetyltransferase]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lin, D]]
[[Category: Lin D]]
[[Category: Lv, Z]]
[[Category: Lv Z]]
[[Category: Shang, H]]
[[Category: Shang H]]
[[Category: Tan, J]]
[[Category: Tan J]]
[[Category: Wang, F]]
[[Category: Wang F]]
[[Category: Xu, X]]
[[Category: Xu X]]
[[Category: Acetyltransferase activity]]
[[Category: Histone acetyltransferase activity]]
[[Category: Transferase]]

Latest revision as of 14:25, 30 October 2024

The Crystal Structure of human MYST1 from Wuxi Biortus.The Crystal Structure of human MYST1 from Wuxi Biortus.

Structural highlights

Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

See Also

7cmr, resolution 2.20Å

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