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New page: '''Unreleased structure''' The entry 7ts2 is ON HOLD Authors: Li, H., Poulos, T.L. Description: Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in comp... |
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==Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 6-(3-(3,3-difluoroazetidin-1-yl)propyl)-4-methylpyridin-2-amine== | |||
<StructureSection load='7ts2' size='340' side='right'caption='[[7ts2]], [[Resolution|resolution]] 1.98Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7ts2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens_environmental_sample Homo sapiens environmental sample]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TS2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TS2 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9758Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=K8F:6-[3-(3,3-difluoroazetidin-1-yl)propyl]-4-methylpyridin-2-amine'>K8F</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ts2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ts2 OCA], [https://pdbe.org/7ts2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ts2 RCSB], [https://www.ebi.ac.uk/pdbsum/7ts2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ts2 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NOS1_HUMAN NOS1_HUMAN] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. | |||
==See Also== | |||
*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: Li | [[Category: Homo sapiens environmental sample]] | ||
[[Category: Poulos | [[Category: Large Structures]] | ||
[[Category: Li H]] | |||
[[Category: Poulos TL]] | |||
Latest revision as of 12:47, 25 October 2023
Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 6-(3-(3,3-difluoroazetidin-1-yl)propyl)-4-methylpyridin-2-amineStructure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 6-(3-(3,3-difluoroazetidin-1-yl)propyl)-4-methylpyridin-2-amine
Structural highlights
FunctionNOS1_HUMAN Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. See Also |
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