3dbq: Difference between revisions
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<StructureSection load='3dbq' size='340' side='right'caption='[[3dbq]], [[Resolution|resolution]] 2.70Å' scene=''> | <StructureSection load='3dbq' size='340' side='right'caption='[[3dbq]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3dbq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3dbq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DBQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DBQ FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dbq OCA], [https://pdbe.org/3dbq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dbq RCSB], [https://www.ebi.ac.uk/pdbsum/3dbq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dbq ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dbq OCA], [https://pdbe.org/3dbq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dbq RCSB], [https://www.ebi.ac.uk/pdbsum/3dbq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dbq ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/db/3dbq_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/db/3dbq_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Ahn | [[Category: Ahn N]] | ||
[[Category: Gao | [[Category: Gao YF]] | ||
[[Category: Lei | [[Category: Lei M]] | ||
[[Category: Liu | [[Category: Liu XD]] | ||
[[Category: Old | [[Category: Old W]] | ||
[[Category: Resing | [[Category: Resing K]] | ||
[[Category: Wang | [[Category: Wang F]] | ||
[[Category: Wang | [[Category: Wang W]] | ||
[[Category: Xu | [[Category: Xu QB]] | ||
[[Category: Yang | [[Category: Yang YT]] | ||
[[Category: Zhu | [[Category: Zhu SC]] | ||