Insulin-like growth factor receptor: Difference between revisions
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<StructureSection load='3i81' size='350' side='right' scene='' caption='Human insulin-like growth factor 1 receptor complex with inhibitor (PDB code [[3i81]])'> | <StructureSection load='3i81' size='350' side='right' scene='' caption='Human insulin-like growth factor 1 receptor complex with inhibitor (PDB code [[3i81]])'> | ||
'''Insulin-like growth factor receptors''' (IGFR) are transmembrane receptors which are stimulated by insulin-like growth factors (IGF). IGFR contains 2 extracellular α chains and 2 transmembranal β chains. Upon binding of IGF, a tyrosine in the β chain becomes autophosphorylated and triggers a cascade of intracellular signaling. The insulin-like growth factor 1 (IGF-1) receptor belongs to the large class of [[Receptor tyrosine kinases|tyrosine kinase receptors]]. See also [[IGF1]], [[Growth factors]]and [[Kinase-linked, enzyme-linked and related receptors]]. | '''Insulin-like growth factor receptors''' (IGFR) are transmembrane receptors which are stimulated by insulin-like growth factors (IGF). IGFR contains 2 extracellular α chains and 2 transmembranal β chains. Upon binding of IGF, a tyrosine in the β chain becomes autophosphorylated and triggers a cascade of intracellular signaling. The insulin-like growth factor 1 (IGF-1) receptor belongs to the large class of [[Receptor tyrosine kinases|tyrosine kinase receptors]]. See also [[IGF1]], [[Growth factors]] and [[Kinase-linked, enzyme-linked and related receptors]]. | ||
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*'''Insulin-like growth factor receptor 1''' is the mediator of the anabolic and mitogenic activity of growth hormone<ref>PMID: 11577173</ref><br /> | |||
*'''Insulin-like growth factor receptor 2''' is a protein hormone regulating cell proliferation, growth, migration, differentiation and survival<ref>PMID: 23257688</ref><br />. | |||
=== Memory-Enhancement by Traditional Chinese Medicine? <ref>doi 10.1080/07391102.2012.741052</ref>=== | === Memory-Enhancement by Traditional Chinese Medicine? <ref>doi 10.1080/07391102.2012.741052</ref>=== | ||
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*IGFR I | *IGFR I | ||
**[[1igr]] – hIGFR I domains 1-3 | **[[1igr]] – hIGFR I domains 1-3 31-492– human<BR /> | ||
**[[1jqh]], [[1p4o]] - hIGFR I kinase domain (mutant) <BR /> | **[[1jqh]], [[1p4o]] - hIGFR I kinase domain (mutant) 983-1286<BR /> | ||
**[[1m7n]] - hIGFR I kinase domain<BR /> | **[[1m7n]] - hIGFR I kinase domain<BR /> | ||
**[[1k3a]] - hIGFR I kinase domain + insulin receptor substrate peptide<BR /> | **[[1k3a]] - hIGFR I kinase domain + insulin receptor substrate peptide<BR /> | ||
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**[[6pyh]] - hIGFR I + IGFI – Cryo EM<BR /> | **[[6pyh]] - hIGFR I + IGFI – Cryo EM<BR /> | ||
**[[6vwg]], [[6vwh]], [[6vwi]], [[6vwj]] - hIGFR I + IGFII – Cryo EM<BR /> | **[[6vwg]], [[6vwh]], [[6vwi]], [[6vwj]] - hIGFR I + IGFII – Cryo EM<BR /> | ||
**[[7s8v]] - hIGFR I + insulin receptor – Cryo EM<BR /> | |||
**[[7s0q]] - hIGFR I + insulin receptor + IGF I – Cryo EM<BR /> | |||
*IGFR II | *IGFR II | ||