2jaz: Difference between revisions

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<StructureSection load='2jaz' size='340' side='right'caption='[[2jaz]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
<StructureSection load='2jaz' size='340' side='right'caption='[[2jaz]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2jaz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecow3 Ecow3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JAZ FirstGlance]. <br>
<table><tr><td colspan='2'>[[2jaz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_str._K-12_substr._W3110 Escherichia coli str. K-12 substr. W3110]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JAZ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ayi|1ayi]], [[1cei|1cei]], [[1mz8|1mz8]], [[1ujz|1ujz]], [[1unk|1unk]], [[1znv|1znv]], [[2erh|2erh]], [[7cei|7cei]], [[1m08|1m08]], [[1pt3|1pt3]], [[1zns|1zns]], [[2axc|2axc]], [[2ivh|2ivh]], [[2jb0|2jb0]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jaz OCA], [https://pdbe.org/2jaz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jaz RCSB], [https://www.ebi.ac.uk/pdbsum/2jaz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jaz ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jaz OCA], [https://pdbe.org/2jaz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jaz RCSB], [https://www.ebi.ac.uk/pdbsum/2jaz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jaz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/IMM7_ECOLX IMM7_ECOLX]] This protein is able to protect a cell, which harbors the plasmid ColE7 encoding colicin E7, against colicin E7, it binds specifically to the DNase-type colicin and inhibits its bactericidal activity. Dimeric ImmE7 may possess a RNase activity that cleaves its own mRNA at a specific site and thus autoregulates translational expression of the downstream ceiE7 gene as well as degradation of the upstream ceaE7 mRNA. [[https://www.uniprot.org/uniprot/CEA7_ECOLX CEA7_ECOLX]] This plasmid-coded bactericidal protein is an endonuclease active on both single- and double-stranded DNA but with undefined specificity.  Colicins are polypeptide toxins produced by and active against E.coli and closely related bacteria.  
[https://www.uniprot.org/uniprot/IMM7_ECOLX IMM7_ECOLX] This protein is able to protect a cell, which harbors the plasmid ColE7 encoding colicin E7, against colicin E7, it binds specifically to the DNase-type colicin and inhibits its bactericidal activity. Dimeric ImmE7 may possess a RNase activity that cleaves its own mRNA at a specific site and thus autoregulates translational expression of the downstream ceiE7 gene as well as degradation of the upstream ceaE7 mRNA.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ecow3]]
[[Category: Escherichia coli str. K-12 substr. W3110]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Huang, H]]
[[Category: Huang H]]
[[Category: Yuan, H S]]
[[Category: Yuan HS]]
[[Category: Antibiotic]]
[[Category: Antimicrobial]]
[[Category: Bacteriocin]]
[[Category: Bacteriocin immunity]]
[[Category: Dna hydrolysis]]
[[Category: Endonuclease]]
[[Category: H-n-h motif]]
[[Category: His metal finger motif]]
[[Category: Hydrolase]]
[[Category: Hydrolase-inhibitor complex]]
[[Category: Hydrolase/inhibitor]]
[[Category: Metal-binding]]
[[Category: Nuclease]]
[[Category: Plasmid]]
[[Category: Toxin]]
[[Category: Zinc]]

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