7qpf: Difference between revisions

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'''Unreleased structure'''


The entry 7qpf is ON HOLD  until Paper Publication
==Discovery of Lu AF11167, a Phosphodiesterase 10A inhibitor clinical candidate==
 
<StructureSection load='7qpf' size='340' side='right'caption='[[7qpf]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
Authors: Leonard, P.M., Langgard, M.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[7qpf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QPF FirstGlance]. <br>
Description: Discovery of Lu AF11167, a Phosphodiesterase 10A inhibitor clinical candidate
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EFJ:2-(1~{H}-benzimidazol-2-ylsulfanylmethyl)-3-bromanyl-5,7-dimethyl-imidazo[1,2-a]pyrimidine'>EFJ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Langgard, M]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qpf OCA], [https://pdbe.org/7qpf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qpf RCSB], [https://www.ebi.ac.uk/pdbsum/7qpf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qpf ProSAT]</span></td></tr>
[[Category: Leonard, P.M]]
</table>
== Function ==
[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Langgard M]]
[[Category: Leonard PM]]

Latest revision as of 10:58, 7 February 2024

Discovery of Lu AF11167, a Phosphodiesterase 10A inhibitor clinical candidateDiscovery of Lu AF11167, a Phosphodiesterase 10A inhibitor clinical candidate

Structural highlights

7qpf is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.7Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PDE10_HUMAN Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.[1]

References

  1. ↑ Wang H, Liu Y, Hou J, Zheng M, Robinson H, Ke H. Structural insight into substrate specificity of phosphodiesterase 10. Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5782-7. Epub 2007 Mar 26. PMID:17389385

7qpf, resolution 1.70Å

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OCA
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