Phospholipase A1: Difference between revisions

Latest revision as of 13:27, 27 August 2023

Function

Phospholipase A1 (PLA1) hydrolyzes phospholipids to produce 2-acyl-lysophospholipids and fatty acids^[1]. PLA1 preferentially hydrolyzes phosphatidic acid and PLA1-phosphatidic acid regulates mitochondria dynamics^[2].

Relevance

Phosphatidylserine-specific PLA1 expression in colorectal cancer is associated with tumor invasion and metastasis^[3].

Phospholiase A1 complex with octylglucoside, glycerol and Ca+2 ion (green) (PDB code 5dqz)

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3D Structures of phospholipase A13D Structures of phospholipase A1

Updated on 27-August-2023

4qnn – PLA1 – hornet
2yij – PLA1 IIγ – Arabidopsis thaliana
7x0c, 7x0d – PLA1 – Capsicum annuum
4hyq – PLA1 – Streptomyces albidoflavus
7ezz – PLA1 – Salmonella typhi

ReferencesReferences

↑ Tani K, Kogure T, Inoue H. The intracellular phospholipase A1 protein family. Biomol Concepts. 2012 Oct;3(5):471-8. doi: 10.1515/bmc-2012-0014. PMID:25436551 doi:http://dx.doi.org/10.1515/bmc-2012-0014
↑ Baba T, Kashiwagi Y, Arimitsu N, Kogure T, Edo A, Maruyama T, Nakao K, Nakanishi H, Kinoshita M, Frohman MA, Yamamoto A, Tani K. Phosphatidic acid (PA)-preferring phospholipase A1 regulates mitochondrial dynamics. J Biol Chem. 2014 Apr 18;289(16):11497-511. doi: 10.1074/jbc.M113.531921. Epub, 2014 Mar 5. PMID:24599962 doi:http://dx.doi.org/10.1074/jbc.M113.531921
↑ Iida Y, Sunami E, Yamashita H, Hiyoshi M, Ishihara S, Yamaguchi H, Inoue A, Makide K, Tsuno NH, Aoki J, Kitayama J, Watanabe T. Phosphatidylserine-specific phospholipase A1 (PS-PLA1) expression in colorectal cancer correlates with tumor invasion and hematogenous metastasis. Anticancer Res. 2015 Mar;35(3):1459-64. PMID:25750298

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Michal Harel, Joel L. Sussman

[1] Tani K, Kogure T, Inoue H. The intracellular phospholipase A1 protein family. Biomol Concepts. 2012 Oct;3(5):471-8. doi: 10.1515/bmc-2012-0014. PMID:25436551 doi:http://dx.doi.org/10.1515/bmc-2012-0014

[2] Baba T, Kashiwagi Y, Arimitsu N, Kogure T, Edo A, Maruyama T, Nakao K, Nakanishi H, Kinoshita M, Frohman MA, Yamamoto A, Tani K. Phosphatidic acid (PA)-preferring phospholipase A1 regulates mitochondrial dynamics. J Biol Chem. 2014 Apr 18;289(16):11497-511. doi: 10.1074/jbc.M113.531921. Epub, 2014 Mar 5. PMID:24599962 doi:http://dx.doi.org/10.1074/jbc.M113.531921

[3] Iida Y, Sunami E, Yamashita H, Hiyoshi M, Ishihara S, Yamaguchi H, Inoue A, Makide K, Tsuno NH, Aoki J, Kitayama J, Watanabe T. Phosphatidylserine-specific phospholipase A1 (PS-PLA1) expression in colorectal cancer correlates with tumor invasion and hematogenous metastasis. Anticancer Res. 2015 Mar;35(3):1459-64. PMID:25750298

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@@ Line 18: / Line 18: @@
 [[4qnn]] – PLA1 – hornet <br />
 [[2yij]] – PLA1 IIγ – ''Arabidopsis thaliana'' <br />
+[[7x0c]], [[7x0d]] – PLA1 – ''Capsicum annuum''<br />
 [[4hyq]] – PLA1 – ''Streptomyces albidoflavus'' <br />
 [[7ezz]] – PLA1 – ''Salmonella typhi'' <br />