2gnk: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2gnk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GNK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GNK FirstGlance]. <br> | <table><tr><td colspan='2'>[[2gnk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GNK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GNK FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gnk OCA], [https://pdbe.org/2gnk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gnk RCSB], [https://www.ebi.ac.uk/pdbsum/2gnk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gnk ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gnk OCA], [https://pdbe.org/2gnk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gnk RCSB], [https://www.ebi.ac.uk/pdbsum/2gnk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gnk ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/GLNK_ECOLI GLNK_ECOLI] P-II indirectly controls the transcription of the glutamine synthetase gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of GlnA. When P-II is uridylylated to P-II-UMP, these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase by GlnE, so activating the enzyme (By similarity). | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Carr | [[Category: Carr PD]] | ||
[[Category: Cheah | [[Category: Cheah E]] | ||
[[Category: Ollis DL]] | |||
[[Category: Ollis | [[Category: Vasudevan SG]] | ||
[[Category: Vasudevan | [[Category: Westerhoff HV]] | ||
[[Category: Westerhoff | [[Category: Xu Y]] | ||
[[Category: Xu | [[Category: Van Heeswijk WC]] | ||
[[Category: | |||