1g0w: Difference between revisions

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[[Image:1g0w.jpg|left|200px]]


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==CRYSTAL STRUCTURE OF BOVINE RETINAL CREATINE KINASE==
The line below this paragraph, containing "STRUCTURE_1g0w", creates the "Structure Box" on the page.
<StructureSection load='1g0w' size='340' side='right'caption='[[1g0w]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1g0w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G0W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G0W FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_1g0w| PDB=1g0w |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g0w OCA], [https://pdbe.org/1g0w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g0w RCSB], [https://www.ebi.ac.uk/pdbsum/1g0w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g0w ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KCRM_BOVIN KCRM_BOVIN] Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g0/1g0w_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1g0w ConSurf].
<div style="clear:both"></div>


'''CRYSTAL STRUCTURE OF BOVINE RETINAL CREATINE KINASE'''
==See Also==
 
*[[Creatine kinase 3D structures|Creatine kinase 3D structures]]
 
__TOC__
==Overview==
</StructureSection>
Creatine kinase (CK) catalyses the reversible transfer of the phosphate moiety from phosphocreatine (PCr) to ADP, generating creatine and ATP. The crystal structure of a cytosolic brain-type creatine kinase is reported at 2.3 A. The biological dimer sits on a crystallographic twofold axis. The N-terminal residues of both subunits come very close to the crystallographic twofold at the dimer interface. The electron density observed is consistent with two alternative conformations for the N-termini, as previously found for chicken brain-type creatine kinase.
 
==About this Structure==
1G0W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G0W OCA].
 
==Reference==
The three-dimensional structure of cytosolic bovine retinal creatine kinase., Tisi D, Bax B, Loew A, Acta Crystallogr D Biol Crystallogr. 2001 Feb;57(Pt 2):187-93. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11173463 11173463]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Creatine kinase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Bax B]]
[[Category: Bax, B.]]
[[Category: Loew A]]
[[Category: Loew, A.]]
[[Category: Tisi D]]
[[Category: Tisi, D.]]
[[Category: Brain-type creatine kinase]]
[[Category: Guanidino kinase cellular energy metabolism]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 16:59:35 2008''

Latest revision as of 10:21, 7 February 2024

CRYSTAL STRUCTURE OF BOVINE RETINAL CREATINE KINASECRYSTAL STRUCTURE OF BOVINE RETINAL CREATINE KINASE

Structural highlights

1g0w is a 1 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.3Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KCRM_BOVIN Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1g0w, resolution 2.30Å

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