2eyz: Difference between revisions

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==CT10-Regulated Kinase isoform II==
==CT10-Regulated Kinase isoform II==
<StructureSection load='2eyz' size='340' side='right'caption='[[2eyz]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
<StructureSection load='2eyz' size='340' side='right'caption='[[2eyz]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2eyz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EYZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EYZ FirstGlance]. <br>
<table><tr><td colspan='2'>[[2eyz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EYZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EYZ FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2eyv|2eyv]], [[2eyw|2eyw]], [[2eyx|2eyx]], [[2eyy|2eyy]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eyz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eyz OCA], [https://pdbe.org/2eyz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eyz RCSB], [https://www.ebi.ac.uk/pdbsum/2eyz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eyz ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eyz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eyz OCA], [https://pdbe.org/2eyz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eyz RCSB], [https://www.ebi.ac.uk/pdbsum/2eyz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eyz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/CRK_HUMAN CRK_HUMAN]] The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.<ref>PMID:1630456</ref> <ref>PMID:11870224</ref> <ref>PMID:17515907</ref>
[https://www.uniprot.org/uniprot/CRK_HUMAN CRK_HUMAN] The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.<ref>PMID:1630456</ref> <ref>PMID:11870224</ref> <ref>PMID:17515907</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Inagaki, F]]
[[Category: Inagaki F]]
[[Category: Kobashigawa, Y]]
[[Category: Kobashigawa Y]]
[[Category: Tanaka, S]]
[[Category: Tanaka S]]
[[Category: Sh2]]
[[Category: Sh3]]
[[Category: Signaling protein]]

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