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<StructureSection load='1h3b' size='340' side='right'caption='[[1h3b]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='1h3b' size='340' side='right'caption='[[1h3b]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1h3b]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_27009 Atcc 27009]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H3B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H3B FirstGlance]. <br>
<table><tr><td colspan='2'>[[1h3b]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Alicyclobacillus_acidocaldarius Alicyclobacillus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H3B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H3B FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene>, <scene name='pdbligand=R46:N-{6-[4-(6-BROMO-1,2-BENZISOTHIAZOL-3-YL)PHENOXY]HEXYL}-N-METHYL-2-PROPEN-1-AMINE'>R46</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1gsz|1gsz]], [[1h35|1h35]], [[1h36|1h36]], [[1h37|1h37]], [[1h39|1h39]], [[1h3a|1h3a]], [[1h3c|1h3c]], [[1sqc|1sqc]], [[2sqc|2sqc]], [[3sqc|3sqc]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene>, <scene name='pdbligand=R46:N-{6-[4-(6-BROMO-1,2-BENZISOTHIAZOL-3-YL)PHENOXY]HEXYL}-N-METHYL-2-PROPEN-1-AMINE'>R46</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Squalene--hopene_cyclase Squalene--hopene cyclase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.17 5.4.99.17] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h3b OCA], [https://pdbe.org/1h3b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h3b RCSB], [https://www.ebi.ac.uk/pdbsum/1h3b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h3b ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h3b OCA], [https://pdbe.org/1h3b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h3b RCSB], [https://www.ebi.ac.uk/pdbsum/1h3b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h3b ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SQHC_ALIAD SQHC_ALIAD] Catalyzes the cyclization of squalene into hopene.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Atcc 27009]]
[[Category: Alicyclobacillus acidocaldarius]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Squalene--hopene cyclase]]
[[Category: Aebi JD]]
[[Category: Aebi, J D]]
[[Category: Dehmlow H]]
[[Category: Dehmlow, H]]
[[Category: Lenhart A]]
[[Category: Lenhart, A]]
[[Category: Morand OH]]
[[Category: Morand, O H]]
[[Category: Reinert DJ]]
[[Category: Reinert, D J]]
[[Category: Schulz GE]]
[[Category: Schulz, G E]]
[[Category: Weihofen WA]]
[[Category: Weihofen, W A]]
[[Category: Cholesterol biosynthesis]]
[[Category: Inhibitor]]
[[Category: Isomerase]]
[[Category: Monotopic membrane protein]]

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