2e8t: Difference between revisions

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<StructureSection load='2e8t' size='340' side='right'caption='[[2e8t]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
<StructureSection load='2e8t' size='340' side='right'caption='[[2e8t]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2e8t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E8T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E8T FirstGlance]. <br>
<table><tr><td colspan='2'>[[2e8t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E8T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E8T FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FPS:S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL]+TRIHYDROGEN+THIODIPHOSPHATE'>FPS</scene>, <scene name='pdbligand=IPE:3-METHYLBUT-3-ENYL+TRIHYDROGEN+DIPHOSPHATE'>IPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.13&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2dh4|2dh4]], [[2e8u|2e8u]], [[2e8v|2e8v]], [[2e8w|2e8w]], [[2e8x|2e8x]], [[2e90|2e90]], [[2e91|2e91]], [[2e92|2e92]], [[2e93|2e93]], [[2e94|2e94]], [[2e95|2e95]], [[2e96|2e96]], [[2e97|2e97]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FPS:S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL]+TRIHYDROGEN+THIODIPHOSPHATE'>FPS</scene>, <scene name='pdbligand=IPE:3-METHYLBUT-3-ENYL+TRIHYDROGEN+DIPHOSPHATE'>IPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Heptaprenyl_diphosphate_synthase Heptaprenyl diphosphate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.30 2.5.1.30] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e8t OCA], [https://pdbe.org/2e8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e8t RCSB], [https://www.ebi.ac.uk/pdbsum/2e8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e8t ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e8t OCA], [https://pdbe.org/2e8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e8t RCSB], [https://www.ebi.ac.uk/pdbsum/2e8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e8t ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/GGPPS_YEAST GGPPS_YEAST]] Catalyzes the trans-addition of the 3 molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate. Required for the membrane attachment of YPT1 and SEC4. May be involved in vesicle trafficking and protein sorting.<ref>PMID:7665600</ref> <ref>PMID:15296494</ref>
[https://www.uniprot.org/uniprot/GGPPS_YEAST GGPPS_YEAST] Catalyzes the trans-addition of the 3 molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate. Required for the membrane attachment of YPT1 and SEC4. May be involved in vesicle trafficking and protein sorting.<ref>PMID:7665600</ref> <ref>PMID:15296494</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Atcc 18824]]
[[Category: Heptaprenyl diphosphate synthase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Chang, T H]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Chen, C K.M]]
[[Category: Chang TH]]
[[Category: Guo, R T]]
[[Category: Chen CK-M]]
[[Category: Jeng, W Y]]
[[Category: Guo RT]]
[[Category: Ko, T P]]
[[Category: Jeng WY]]
[[Category: Liang, P H]]
[[Category: Ko TP]]
[[Category: Oldfield, E]]
[[Category: Liang PH]]
[[Category: Wang, A H.J]]
[[Category: Oldfield E]]
[[Category: Bisphosphonate]]
[[Category: Wang AH-J]]
[[Category: Farnesyl pyrophosphate]]
[[Category: Prenyltransferase]]
[[Category: Transferase]]

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