Protein Kinases: Difference between revisions

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New page: <StructureSection load='' size='350' side='right' scene='48/483859/Cv/1' caption='Human Fyn tyrosine kinase kinase domain with phosphotyrosine in stick model complex with inhibitor stauros...
 
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<StructureSection load='' size='350' side='right' scene='48/483859/Cv/1' caption='Human Fyn tyrosine kinase kinase domain with phosphotyrosine in stick model complex with inhibitor staurosporine (PDB code [[2dq7]]).' pspeed='8'>
<StructureSection load='' size='350' side='right' scene='48/483859/Cv/1' caption='Human Fyn tyrosine kinase kinase domain with phosphotyrosine in stick model complex with inhibitor staurosporine (PDB code [[2dq7]]).'>
This is a default text for your page '''Protein Kinases'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
*[[Calcium-dependent protein kinase]]
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
*[[Calcium/Calmodulin-dependent protein kinase]]
*[[Eukaryotic Protein Kinase Catalytic Domain]]
*[[Interleukin-1 receptor-associated kinase]]


== Function ==
''Tyrosine kinases:''
*[[Receptor tyrosine kinases]]
*[[Tyrosine kinase]]
*[[Janus kinase]] or tyrosine-protein kinase JAK (JAK) are nonreceptor tyrosine kinases which transduces cytokine-mediated signals via the JAK-STAT pathway. The JAK-STAT pathway transmits signals through the cell membrane to DNA promoters thus causing transcription.


== Disease ==
''Serine/threonine protein kinase''
*[[Serine/threonine protein kinase]]


== Relevance ==
''Protein kinase C''
*[[Protein kinase C]]
*The sensitization of [[TRPV1]] is thought to be connected to phosphorylation by [[protein kinase C]] and the cleavage of PIP2.
 
''MAPK''
*[[Mitogen-activated protein kinase]]
*[[Mitogen-activated protein kinase kinase]]
*[[Mitogen-activated protein kinase kinase kinase]]
*[[Michael Roberts/BIOL115/ERK2]]
*[[UMass Chem 423 Student Projects 2011-2#p38 kinase|p38 MAPK (UMass Chem 423 Student Projects 2011-2)]]
 
''CAMP-dependent protein kinase''
*[[CAMP-dependent protein kinase]]
*[[CAMP Dependent Protein Kinase, Catalytic Subunit]]
*[[Protein Kinase A]]


== Structural highlights ==


This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.


</StructureSection>
</StructureSection>
== References ==
== References ==
<references/>
<references/>

Latest revision as of 16:10, 9 February 2022

Tyrosine kinases:

  • Receptor tyrosine kinases
  • Tyrosine kinase
  • Janus kinase or tyrosine-protein kinase JAK (JAK) are nonreceptor tyrosine kinases which transduces cytokine-mediated signals via the JAK-STAT pathway. The JAK-STAT pathway transmits signals through the cell membrane to DNA promoters thus causing transcription.

Serine/threonine protein kinase

Protein kinase C

MAPK

CAMP-dependent protein kinase



Human Fyn tyrosine kinase kinase domain with phosphotyrosine in stick model complex with inhibitor staurosporine (PDB code 2dq7).

Drag the structure with the mouse to rotate

ReferencesReferences

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky