2k1k: Difference between revisions
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==NMR structures of dimeric transmembrane domain of the receptor tyrosine kinase EphA1 in lipid bicelles at pH 4.3== | ==NMR structures of dimeric transmembrane domain of the receptor tyrosine kinase EphA1 in lipid bicelles at pH 4.3== | ||
<StructureSection load='2k1k' size='340' side='right'caption='[[2k1k | <StructureSection load='2k1k' size='340' side='right'caption='[[2k1k]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2k1k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2k1k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K1K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K1K FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k1k OCA], [https://pdbe.org/2k1k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k1k RCSB], [https://www.ebi.ac.uk/pdbsum/2k1k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k1k ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k1k OCA], [https://pdbe.org/2k1k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k1k RCSB], [https://www.ebi.ac.uk/pdbsum/2k1k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k1k ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/EPHA1_HUMAN EPHA1_HUMAN] Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.<ref>PMID:17634955</ref> <ref>PMID:19118217</ref> <ref>PMID:20043122</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arseniev | [[Category: Arseniev AS]] | ||
[[Category: Bocharov | [[Category: Bocharov EV]] | ||
[[Category: Goncharuk | [[Category: Goncharuk MV]] | ||
[[Category: Mayzel | [[Category: Mayzel ML]] | ||