2c63: Difference between revisions
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<StructureSection load='2c63' size='340' side='right'caption='[[2c63]], [[Resolution|resolution]] 2.15Å' scene=''> | <StructureSection load='2c63' size='340' side='right'caption='[[2c63]], [[Resolution|resolution]] 2.15Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2c63]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2c63]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C63 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C63 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c63 OCA], [https://pdbe.org/2c63 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c63 RCSB], [https://www.ebi.ac.uk/pdbsum/2c63 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c63 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c63 OCA], [https://pdbe.org/2c63 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c63 RCSB], [https://www.ebi.ac.uk/pdbsum/2c63 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c63 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/1433F_HUMAN 1433F_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.<ref>PMID:12177059</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c6/2c63_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c6/2c63_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith C]] | ||
[[Category: Doyle | [[Category: Doyle DA]] | ||
[[Category: Edwards | [[Category: Edwards A]] | ||
[[Category: Elkins | [[Category: Elkins JM]] | ||
[[Category: Johansson | [[Category: Johansson C]] | ||
[[Category: Smee | [[Category: Smee CEA]] | ||
[[Category: Sundstrom | [[Category: Sundstrom M]] | ||
[[Category: Weigelt | [[Category: Weigelt J]] | ||
[[Category: Yang | [[Category: Yang X]] | ||