2bo2: Difference between revisions
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<StructureSection load='2bo2' size='340' side='right'caption='[[2bo2]], [[Resolution|resolution]] 2.60Å' scene=''> | <StructureSection load='2bo2' size='340' side='right'caption='[[2bo2]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2bo2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2bo2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BO2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BO2 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bo2 OCA], [https://pdbe.org/2bo2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bo2 RCSB], [https://www.ebi.ac.uk/pdbsum/2bo2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bo2 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bo2 OCA], [https://pdbe.org/2bo2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bo2 RCSB], [https://www.ebi.ac.uk/pdbsum/2bo2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bo2 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/AGRE2_HUMAN AGRE2_HUMAN] Vibratory urticaria. The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/AGRE2_HUMAN AGRE2_HUMAN] Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Is a regulator of mast cell degranulation (PubMed:26841242).<ref>PMID:12829604</ref> <ref>PMID:17928360</ref> <ref>PMID:22310662</ref> <ref>PMID:22575658</ref> <ref>PMID:26841242</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bo/2bo2_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bo/2bo2_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Abbott | [[Category: Abbott RJM]] | ||
[[Category: Handford | [[Category: Handford PA]] | ||
[[Category: Knott | [[Category: Knott V]] | ||
[[Category: Lea | [[Category: Lea SM]] | ||
[[Category: McDonnell | [[Category: McDonnell JM]] | ||
[[Category: Roversi | [[Category: Roversi P]] | ||
[[Category: Spendlove | [[Category: Spendlove I]] | ||
[[Category: Teriete | [[Category: Teriete P]] | ||