Phospholipase C: Difference between revisions
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*'''Phospholipase C δ''' is critical for Ca+2 homeostasis. | *'''Phospholipase C δ''' is critical for Ca+2 homeostasis. | ||
*'''Phospholipase C ε''' is an effector for Ras. | *'''Phospholipase C ε''' is an effector for Ras. | ||
*'''Phosphatidylinositol-specific phospholipase C''' (PIPLC) catalyzes the hydrolysis of phosphatidylinositol into inositol triphosphate and deacylglycerol. PIPLC functions at the plasma membrane. PIPLC can release phosphatidylinositol-linked proteins (i.e., acetylcholinesterase) from the membrane by enzymatically cleaving their GPI anchor. <ref>PMID:11249190</ref> | *'''Phosphatidylinositol-specific phospholipase C''' (PIPLC) catalyzes the hydrolysis of phosphatidylinositol into inositol triphosphate and deacylglycerol. PIPLC functions at the plasma membrane. PIPLC can release phosphatidylinositol-linked proteins (i.e., acetylcholinesterase) from the membrane by enzymatically cleaving their GPI anchor. <ref>PMID:11249190</ref>. See also [[IP3 is second messenger]]. | ||
== Disease == | == Disease == | ||
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**[[2zkm]] – hPLCB-2 - human<br /> | **[[2zkm]] – hPLCB-2 - human<br /> | ||
**[[2fju]] – hPLCB-2 + RAC1<br /> | **[[2fju]] – hPLCB-2 + RAC1<br /> | ||
**[[8emv]] – hPLCB-3 – Cryo EM <br /> | |||
**[[7sq2]], [[4gnk]], [[4qj3]] – hPLCB-3 + guanine nucleotide-binding protein G subunit alpha<br /> | **[[7sq2]], [[4gnk]], [[4qj3]] – hPLCB-3 + guanine nucleotide-binding protein G subunit alpha<br /> | ||
**[[4qj4]], [[4qj5]] – hPLCB-3 + guanine nucleotide-binding protein G subunit alpha + inositol phosphate derivative <br /> | **[[4qj4]], [[4qj5]] – hPLCB-3 + guanine nucleotide-binding protein G subunit alpha + inositol phosphate derivative <br /> | ||
**[[7sq2]] – hPLCB-3 + guanine nucleotide-binding protein G subunit alpha + GDP <br /> | |||
**[[8emw]], [[8emx]] – hPLCB-3 + guanine nucleotide-binding protein G subunits beta+gamma – Cryo EM <br /> | |||
**[[1jad]] – PLCB - turkey<br /> | **[[1jad]] – PLCB - turkey<br /> | ||
**[[3qr0]] – PLCB - cuttlefish<br /> | **[[3qr0]] – PLCB - cuttlefish<br /> | ||
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**[[2w2x]] – hPLCG-2 split PH2 domain + RAC2 br /> | **[[2w2x]] – hPLCG-2 split PH2 domain + RAC2 br /> | ||
**[[4ey0]] – hPLCG-1 SH2 domain (mutant)<br /> | **[[4ey0]] – hPLCG-1 SH2 domain (mutant)<br /> | ||
**[[7nxe]] – hPLCG-1 SH2 domain + peptide<br /> | |||
**[[2pld]], [[2ple]] – PLCG C terminal SH2 domain + PDGF peptide – bovine - NMR <br /> | **[[2pld]], [[2ple]] – PLCG C terminal SH2 domain + PDGF peptide – bovine - NMR <br /> | ||
**[[1ywp]] – rPLCG-1 SH3 domain | **[[6pbc]] – rPLCG-1 – rat<br /> | ||
**[[1ywp]] – rPLCG-1 SH3 domain 790-851<br /> | |||
**[[1y0m]] – rPLCG-1 SH3 domain (mutant)<br /> | **[[1y0m]] – rPLCG-1 SH3 domain (mutant)<br /> | ||
**[[2fjl]] – rPLCG-1 split PH2 domain - NMR<br /> | **[[2fjl]] – rPLCG-1 split PH2 domain - NMR<br /> | ||
**[[2eob]] – rPLCG-2 SH2 domain - NMR<br /> | **[[2eob]] – rPLCG-2 SH2 domain 633-743 - NMR<br /> | ||
**[[1ywo]] – rPLCG-1 SH3 domain + lymphocyte cytosolic protein peptide <br /> | **[[1ywo]] – rPLCG-1 SH3 domain + lymphocyte cytosolic protein peptide <br /> | ||
**[[7z3j]] – rPLCG-1 + inositol-3P <br /> | |||
**[[4k44]], [[4k45]] – rPLCG C terminal SH2 domain <br /> | **[[4k44]], [[4k45]] – rPLCG C terminal SH2 domain <br /> | ||
**[[2dx0]] – mPLCG-2 N terminal SH2 domain – mouse<br /> | **[[2dx0]] – mPLCG-2 N terminal SH2 domain – mouse<br /> | ||
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**[[2bye]] – hPLCE-1 RA1 domain - NMR <br /> | **[[2bye]] – hPLCE-1 RA1 domain - NMR <br /> | ||
**[[2byf]] – hPLCE-1 RA2 domain - NMR <br /> | **[[2byf]] – hPLCE-1 RA2 domain - NMR <br /> | ||
**[[6pmp]] – rPLCE-1 RA1 domain <br /> | |||
* Phospholipase C | * Phospholipase C | ||
**[[8hav]], [[8haw]] – BcPLC4 (mutant) – ''Arabidopsis thaliana''<br /> | |||
**[[1ah7]] – BcPLC<br /> | **[[1ah7]] – BcPLC<br /> | ||
**[[1p5x]], [[2ffz]], [[2fgn]], [[2huc]] – BcPLC (mutant)<br /> | **[[1p5x]], [[2ffz]], [[2fgn]], [[2huc]] – BcPLC (mutant)<br /> | ||