1ym5: Difference between revisions

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<StructureSection load='1ym5' size='340' side='right'caption='[[1ym5]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
<StructureSection load='1ym5' size='340' side='right'caption='[[1ym5]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1ym5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YM5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YM5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1ym5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YM5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YM5 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ym5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ym5 OCA], [https://pdbe.org/1ym5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ym5 RCSB], [https://www.ebi.ac.uk/pdbsum/1ym5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ym5 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ym5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ym5 OCA], [https://pdbe.org/1ym5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ym5 RCSB], [https://www.ebi.ac.uk/pdbsum/1ym5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ym5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/YHI9_YEAST YHI9_YEAST]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ym5 ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ym5 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
In the Pseudomonas bacterial genomes, the PhzF proteins are involved in the production of phenazine derivative antibiotic and antifungal compounds. The PhzF superfamily however also encompasses proteins in all genomes from bacteria to eukaryotes, for which no function has been assigned. We have determined the three dimensional crystal structure at 2.05 A resolution of YHI9, the yeast member of the PhzF family. YHI9 has a fold similar to bacterial diaminopimelate epimerase, revealing a bimodular structure with an internal symmetry. Residue conservation identifies a putative active site at the interface between the two domains. Evolution of this protein by gene duplication, gene fusion and domain swapping from an ancestral gene containing the "hot dog" fold, identifies the protein as a "kinked double hot dog" fold.
Crystal structure of YHI9, the yeast member of the phenazine biosynthesis PhzF enzyme superfamily.,Liger D, Quevillon-Cheruel S, Sorel I, Bremang M, Blondeau K, Aboulfath I, Janin J, van Tilbeurgh H, Leulliot N Proteins. 2005 Sep 1;60(4):778-86. PMID:16021630<ref>PMID:16021630</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1ym5" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Atcc 18824]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Aboulfath, I]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Blondeau, K]]
[[Category: Aboulfath I]]
[[Category: Bremang, M]]
[[Category: Blondeau K]]
[[Category: Janin, J]]
[[Category: Bremang M]]
[[Category: Leulliot, N]]
[[Category: Janin J]]
[[Category: Liger, D]]
[[Category: Leulliot N]]
[[Category: Quevillon-Cheruel, S]]
[[Category: Liger D]]
[[Category: Sorel, I]]
[[Category: Quevillon-Cheruel S]]
[[Category: Tilbeurgh, H Van]]
[[Category: Sorel I]]
[[Category: Structural genomic]]
[[Category: Van Tilbeurgh H]]
[[Category: Double hot-dog]]
[[Category: Oxidoreductase]]
[[Category: Phzf enzyme superfamily]]
[[Category: Ysg]]

Latest revision as of 16:38, 13 March 2024

Crystal structure of YHI9, the yeast member of the phenazine biosynthesis PhzF enzyme superfamily.Crystal structure of YHI9, the yeast member of the phenazine biosynthesis PhzF enzyme superfamily.

Structural highlights

1ym5 is a 1 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.05Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

YHI9_YEAST

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

1ym5, resolution 2.05Å

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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