1v35: Difference between revisions
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<StructureSection load='1v35' size='340' side='right'caption='[[1v35]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='1v35' size='340' side='right'caption='[[1v35]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1v35]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1v35]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V35 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V35 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v35 OCA], [https://pdbe.org/1v35 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v35 RCSB], [https://www.ebi.ac.uk/pdbsum/1v35 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v35 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v35 OCA], [https://pdbe.org/1v35 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v35 RCSB], [https://www.ebi.ac.uk/pdbsum/1v35 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v35 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/Q9BJJ9_PLAFA Q9BJJ9_PLAFA] | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Plasmodium falciparum]] | ||
[[Category: Kapoor | [[Category: Kapoor M]] | ||
[[Category: Suguna | [[Category: Suguna K]] | ||
[[Category: Surolia | [[Category: Surolia A]] | ||
[[Category: SwarnaMukhi | [[Category: SwarnaMukhi PL]] | ||
[[Category: Surolia | [[Category: Surolia N]] | ||
Latest revision as of 10:43, 25 October 2023
Crystal Structure of Eoyl-ACP Reductase with NADHCrystal Structure of Eoyl-ACP Reductase with NADH
Structural highlights
FunctionEvolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedBacteria synthesize fatty acids in a dissociated type pathway different from that in humans. Enoyl acyl carrier protein reductase, which catalyzes the final step of fatty acid elongation, has been validated as a potential anti-microbial drug target. Triclosan is known to inhibit this enzyme effectively. Precise characterization of the mode of triclosan binding is required to develop highly specific inhibitors. With this in view, interactions between triclosan, the cofactor NADH/NAD+ and the enzyme from five different species, one plant and four of microbial origin, have been examined in the available crystal structures. A comparison of these structures shows major structural differences at the substrate/inhibitor/cofactor-binding loop. The analysis reveals that the conformation of this flexible loop and the binding affinities of triclosan to each of these enzymes are strongly correlated. Structural basis for the variation in triclosan affinity to enoyl reductases.,Pidugu LS, Kapoor M, Surolia N, Surolia A, Suguna K J Mol Biol. 2004 Oct 8;343(1):147-55. PMID:15381426[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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