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==EGFR L858R/V948R in complex with osimertinib and allosteric inhibitor JBJ-09-063== | ==EGFR L858R/V948R in complex with osimertinib and allosteric inhibitor JBJ-09-063== | ||
<StructureSection load='7k1h' size='340' side='right'caption='[[7k1h]]' scene=''> | <StructureSection load='7k1h' size='340' side='right'caption='[[7k1h]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K1H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7K1H FirstGlance]. <br> | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K1H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7K1H FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k1h OCA], [https://pdbe.org/7k1h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k1h RCSB], [https://www.ebi.ac.uk/pdbsum/7k1h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k1h ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.602Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VNS:(2R)-2-(5-fluoro-2-hydroxyphenyl)-2-{6-[4-(1-methylpiperidin-4-yl)phenyl]-1-oxo-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide'>VNS</scene>, <scene name='pdbligand=YY3:N-(2-{[2-(DIMETHYLAMINO)ETHYL](METHYL)AMINO}-4-METHOXY-5-{[4-(1-METHYL-1H-INDOL-3-YL)PYRIMIDIN-2-YL]AMINO}PHENYL)PROP-2-ENAMIDE'>YY3</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k1h OCA], [https://pdbe.org/7k1h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k1h RCSB], [https://www.ebi.ac.uk/pdbsum/7k1h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k1h ProSAT]</span></td></tr> | |||
</table> | </table> | ||
==See Also== | |||
*[[Epidermal growth factor receptor 3D structures|Epidermal growth factor receptor 3D structures]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Latest revision as of 09:26, 21 November 2024
EGFR L858R/V948R in complex with osimertinib and allosteric inhibitor JBJ-09-063EGFR L858R/V948R in complex with osimertinib and allosteric inhibitor JBJ-09-063
Structural highlights
See Also |
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