1kcm: Difference between revisions

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<StructureSection load='1kcm' size='340' side='right'caption='[[1kcm]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='1kcm' size='340' side='right'caption='[[1kcm]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1kcm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KCM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KCM FirstGlance]. <br>
<table><tr><td colspan='2'>[[1kcm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KCM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KCM FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1fvz|1fvz]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kcm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kcm OCA], [https://pdbe.org/1kcm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kcm RCSB], [https://www.ebi.ac.uk/pdbsum/1kcm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kcm ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kcm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kcm OCA], [https://pdbe.org/1kcm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kcm RCSB], [https://www.ebi.ac.uk/pdbsum/1kcm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kcm ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[https://www.uniprot.org/uniprot/PIPNA_MOUSE PIPNA_MOUSE]] Note=Defects in Pitpna are the cause of the vibrator phenotype which is characterized by early-onset progressive action tremor, degeneration of brain stem and spinal cord neurons, and juvenile death. The mutation is due to the insertion of an intracisternal A particle retrotransposon in intron 4 which results in a 5-fold reduction in protein levels.  
[https://www.uniprot.org/uniprot/PIPNA_MOUSE PIPNA_MOUSE] Note=Defects in Pitpna are the cause of the vibrator phenotype which is characterized by early-onset progressive action tremor, degeneration of brain stem and spinal cord neurons, and juvenile death. The mutation is due to the insertion of an intracisternal A particle retrotransposon in intron 4 which results in a 5-fold reduction in protein levels.
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/PIPNA_MOUSE PIPNA_MOUSE]] Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes.  
[https://www.uniprot.org/uniprot/PIPNA_MOUSE PIPNA_MOUSE] Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Agianian, B]]
[[Category: Agianian B]]
[[Category: Gros, P]]
[[Category: Gros P]]
[[Category: Kroon, J]]
[[Category: Kroon J]]
[[Category: Schouten, A]]
[[Category: Schouten A]]
[[Category: Westerman, J]]
[[Category: Westerman J]]
[[Category: Wirtz, K W.A]]
[[Category: Wirtz KWA]]
[[Category: Lipid binding protein]]
[[Category: Phospholipid binding protein]]
[[Category: Phospholipid transport]]
[[Category: Pitp]]

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