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==Cryo-EM structure of Isocitrate lyase-1 from Candida albicans== | ==Cryo-EM structure of Isocitrate lyase-1 from Candida albicans== | ||
<StructureSection load='7ebf' size='340' side='right'caption='[[7ebf]]' scene=''> | <StructureSection load='7ebf' size='340' side='right'caption='[[7ebf]], [[Resolution|resolution]] 2.63Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EBF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EBF FirstGlance]. <br> | <table><tr><td colspan='2'>[[7ebf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EBF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EBF FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ebf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ebf OCA], [https://pdbe.org/7ebf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ebf RCSB], [https://www.ebi.ac.uk/pdbsum/7ebf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ebf ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.63Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ebf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ebf OCA], [https://pdbe.org/7ebf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ebf RCSB], [https://www.ebi.ac.uk/pdbsum/7ebf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ebf ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/ACEA_CANAX ACEA_CANAX] Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2-methylisocitrate.[UniProtKB:P28240] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Candida albicans]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Hamaguchi T]] | [[Category: Hamaguchi T]] | ||
Latest revision as of 13:54, 27 March 2024
Cryo-EM structure of Isocitrate lyase-1 from Candida albicansCryo-EM structure of Isocitrate lyase-1 from Candida albicans
Structural highlights
FunctionACEA_CANAX Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2-methylisocitrate.[UniProtKB:P28240] |
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