1eo1: Difference between revisions

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-[[Image:1eo1.gif|left|200px]]
-<!--
+==Solution structure of hypothetical protein MTH1175 from Methanobacterium thermoautotrophicum==
-The line below this paragraph, containing "STRUCTURE_1eo1", creates the "Structure Box" on the page.
+<StructureSection load='1eo1' size='340' side='right'caption='[[1eo1]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1eo1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EO1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EO1 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1eo1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eo1 OCA], [https://pdbe.org/1eo1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1eo1 RCSB], [https://www.ebi.ac.uk/pdbsum/1eo1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1eo1 ProSAT], [https://www.topsan.org/Proteins/NESGC/1eo1 TOPSAN]</span></td></tr>
-{{STRUCTURE_1eo1|  PDB=1eo1  |  SCENE=  }}
+</table>
+== Function ==
-'''Solution structure of hypothetical protein MTH1175 from Methanobacterium thermoautotrophicum'''
+[https://www.uniprot.org/uniprot/O27243_METTH O27243_METTH]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
-==Overview==
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eo/1eo1_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1eo1 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
 The solution structure of MTH1175, a 124-residue protein from the archaeon Methanobacterium thermoautotrophicum has been determined by NMR spectroscopy. MTH1175 is part of a family of conserved hypothetical proteins (COG1433) with unknown functions which contains multiple paralogs from all complete archaeal genomes and the archaeal gene-rich bacterium Thermotoga maritima. Sequence similarity indicates this protein family may be related to the nitrogen fixation proteins NifB and NifX. MTH1175 adopts an alpha/beta topology with a single mixed beta-sheet, and contains two flexible loops and an unstructured C-terminal tail. The fold resembles that of Ribonuclease H and similar proteins, but differs from these in several respects, and is not likely to have a nuclease activity.
-==About this Structure==
+NMR structure determination and structure-based functional characterization of conserved hypothetical protein MTH1175 from Methanobacterium thermoautotrophicum.,Cort JR, Yee A, Edwards AM, Arrowsmith CH, Kennedy MA J Struct Funct Genomics. 2000;1(1):15-25. PMID:12836677<ref>PMID:12836677</ref>
-EO1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EO1 OCA].
-==Reference==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-NMR structure determination and structure-based functional characterization of conserved hypothetical protein MTH1175 from Methanobacterium thermoautotrophicum., Cort JR, Yee A, Edwards AM, Arrowsmith CH, Kennedy MA, J Struct Funct Genomics. 2000;1(1):15-25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12836677 12836677]
+</div>
+<div class="pdbe-citations 1eo1" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Methanothermobacter thermautotrophicus]]
-[[Category: Single protein]]
+[[Category: Arrowsmith CH]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Cort JR]]
-[[Category: Cort, J R.]]
+[[Category: Kennedy MA]]
-[[Category: Kennedy, M A.]]
-[[Category: NESG, Northeast Structural Genomics Consortium.]]
-[[Category: Mixed a/b protein]]
-[[Category: Mixed beta sheet]]
-[[Category: Nesg]]
-[[Category: Northeast structural genomics consortium]]
-[[Category: Protein structure initiative]]
-[[Category: Psi]]
-[[Category: Strand order 321456,strands 2 and 6 antiparallel to rest.]]
-[[Category: Structural genomic]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 15:19:47 2008''