2otp: Difference between revisions

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<StructureSection load='2otp' size='340' side='right'caption='[[2otp]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='2otp' size='340' side='right'caption='[[2otp]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2otp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OTP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OTP FirstGlance]. <br>
<table><tr><td colspan='2'>[[2otp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OTP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OTP FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LILRA2, ILT1, LIR7 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2otp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2otp OCA], [https://pdbe.org/2otp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2otp RCSB], [https://www.ebi.ac.uk/pdbsum/2otp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2otp ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2otp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2otp OCA], [https://pdbe.org/2otp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2otp RCSB], [https://www.ebi.ac.uk/pdbsum/2otp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2otp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/LIRA2_HUMAN LIRA2_HUMAN]] Does not bind class I MHC antigens.<ref>PMID:19230061</ref>
[https://www.uniprot.org/uniprot/LIRA2_HUMAN LIRA2_HUMAN] Does not bind class I MHC antigens.<ref>PMID:19230061</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ot/2otp_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ot/2otp_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Chen, Y]]
[[Category: Chen Y]]
[[Category: Gao, F]]
[[Category: Gao F]]
[[Category: Gao, G F]]
[[Category: Gao GF]]
[[Category: Liu, Y]]
[[Category: Liu Y]]
[[Category: Peng, H]]
[[Category: Peng H]]
[[Category: Activating receptor]]
[[Category: Dimer]]
[[Category: Domain swapping]]
[[Category: Ilt1]]
[[Category: Immune system]]
[[Category: Monomer]]

Latest revision as of 11:25, 30 October 2024

Crystal Structure of Immunoglobulin-Like Transcript 1 (ILT1/LIR7/LILRA2)Crystal Structure of Immunoglobulin-Like Transcript 1 (ILT1/LIR7/LILRA2)

Structural highlights

2otp is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.6Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

LIRA2_HUMAN Does not bind class I MHC antigens.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. Chen Y, Gao F, Chu F, Peng H, Zong L, Liu Y, Tien P, Gao GF. Crystal structure of myeloid cell activating receptor leukocyte Ig-like receptor A2 (LILRA2/ILT1/LIR-7) domain swapped dimer: molecular basis for its non-binding to MHC complexes. J Mol Biol. 2009 Feb 27;386(3):841-53. PMID:19230061

2otp, resolution 2.60Å

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA