1gwp: Difference between revisions
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==STRUCTURE OF THE N-TERMINAL DOMAIN OF THE MATURE HIV-1 CAPSID PROTEIN== | ==STRUCTURE OF THE N-TERMINAL DOMAIN OF THE MATURE HIV-1 CAPSID PROTEIN== | ||
<StructureSection load='1gwp' size='340' side='right'caption='[[1gwp | <StructureSection load='1gwp' size='340' side='right'caption='[[1gwp]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1gwp]] is a 1 chain structure. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1gds 1gds], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1gdy 1gdy] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1gdz 1gdz]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GWP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GWP FirstGlance]. <br> | <table><tr><td colspan='2'>[[1gwp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_(NEW_YORK-5_ISOLATE) Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE)]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1gds 1gds], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1gdy 1gdy] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1gdz 1gdz]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GWP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GWP FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gwp OCA], [https://pdbe.org/1gwp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gwp RCSB], [https://www.ebi.ac.uk/pdbsum/1gwp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gwp ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gwp OCA], [https://pdbe.org/1gwp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gwp RCSB], [https://www.ebi.ac.uk/pdbsum/1gwp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gwp ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/GAG_HV1N5 GAG_HV1N5] Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu. Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity). | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Gitti | [[Category: Gitti RK]] | ||
[[Category: Lee | [[Category: Lee BM]] | ||
[[Category: Summers | [[Category: Summers MF]] | ||
[[Category: Sundquist | [[Category: Sundquist WI]] | ||
[[Category: Tang | [[Category: Tang C]] | ||
[[Category: Walker | [[Category: Walker J]] | ||
[[Category: Yoo | [[Category: Yoo S]] | ||