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<StructureSection load='1a8e' size='340' side='right'caption='[[1a8e]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='1a8e' size='340' side='right'caption='[[1a8e]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1a8e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A8E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A8E FirstGlance]. <br>
<table><tr><td colspan='2'>[[1a8e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A8E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A8E FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a8e OCA], [https://pdbe.org/1a8e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a8e RCSB], [https://www.ebi.ac.uk/pdbsum/1a8e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a8e ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a8e OCA], [https://pdbe.org/1a8e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a8e RCSB], [https://www.ebi.ac.uk/pdbsum/1a8e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a8e ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[https://omim.org/entry/209300 209300]]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref> <ref>PMID:15466165</ref>
[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[https://omim.org/entry/209300 209300]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref> <ref>PMID:15466165</ref>  
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.  
[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a8/1a8e_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a8/1a8e_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Anderson, B F]]
[[Category: Anderson BF]]
[[Category: Baker, E N]]
[[Category: Baker EN]]
[[Category: Baker, H]]
[[Category: Baker H]]
[[Category: Bewley, M]]
[[Category: Bewley M]]
[[Category: Brayer, G D]]
[[Category: Brayer GD]]
[[Category: Chen, J]]
[[Category: Chen J]]
[[Category: Luo, Y]]
[[Category: Luo Y]]
[[Category: Macgillivray, R T.A]]
[[Category: Macgillivray RTA]]
[[Category: Mason, A B]]
[[Category: Mason AB]]
[[Category: Moore, S A]]
[[Category: Moore SA]]
[[Category: Murphy, M E.P]]
[[Category: Murphy MEP]]
[[Category: Smith, C A]]
[[Category: Smith CA]]
[[Category: Wang, Y]]
[[Category: Wang Y]]
[[Category: Woodworth, R C]]
[[Category: Woodworth RC]]
[[Category: Carbonate]]
[[Category: Glycoprotein]]
[[Category: Iron transport]]
[[Category: Iron-release]]
[[Category: Nlobe]]
[[Category: Transferrin]]

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