2jsd: Difference between revisions

<StructureSection load='2jsd' size='340' side='right'caption='[[2jsd]]' scene=''>

<table><tr><td colspan='2'>[[2jsd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JSD FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NGH:N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL+HYDROXAMIC+ACID'>NGH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[https://www.uniprot.org/uniprot/MMP20_HUMAN MMP20_HUMAN] Defects in MMP20 are the cause of amelogenesis imperfecta hypomaturation type 2A2 (AI2A2) [MIM:[https://omim.org/entry/612529 612529]. AI2A2 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.<ref>PMID:15744043</ref>  

[https://www.uniprot.org/uniprot/MMP20_HUMAN MMP20_HUMAN] Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation.<ref>PMID:9398237</ref> <ref>PMID:10922468</ref>  

[[Category: Homo sapiens]]

[[Category: Arendt Y]]

[[Category: Banci L]]

[[Category: Bertini I]]

[[Category: Cantini F]]

[[Category: Cozzi R]]

[[Category: Del Conte R]]

[[Category: Gonnelli L]]