3plc: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3plc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Ophiophagus_hannah Ophiophagus hannah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PLC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PLC FirstGlance]. <br> | <table><tr><td colspan='2'>[[3plc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Ophiophagus_hannah Ophiophagus hannah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PLC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PLC FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3plc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3plc OCA], [https://pdbe.org/3plc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3plc RCSB], [https://www.ebi.ac.uk/pdbsum/3plc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3plc ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.41Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3plc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3plc OCA], [https://pdbe.org/3plc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3plc RCSB], [https://www.ebi.ac.uk/pdbsum/3plc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3plc ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/3SDC7_OPHHA 3SDC7_OPHHA] Acts as a beta-blocker by binding to beta-1 and beta-2 adrenergic receptors (ADRB1 and ADRB2). It dose-dependently decreases the heart rate (bradycardia), whereas conventional cardiotoxins increases it. At 100 mg/kg, intraperitoneal injection into mice provokes labored breathing, impaired locomotion, lack of response to external stimuli, and death (after 30 min).<ref>PMID:17616557</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Ophiophagus hannah]] | [[Category: Ophiophagus hannah]] | ||
[[Category: Kini | [[Category: Kini RM]] | ||
[[Category: Qingxiang | [[Category: Qingxiang S]] | ||
[[Category: Roy | [[Category: Roy A]] | ||
[[Category: Sivaraman | [[Category: Sivaraman J]] | ||