2he7: Difference between revisions

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 <StructureSection load='2he7' size='340' side='right'caption='[[2he7]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2he7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HE7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HE7 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2he7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HE7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HE7 FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EPB41L3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2he7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2he7 OCA], [https://pdbe.org/2he7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2he7 RCSB], [https://www.ebi.ac.uk/pdbsum/2he7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2he7 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/E41L3_HUMAN E41L3_HUMAN]] Critical growth regulator in the pathogenesis of meningiomas.
+[https://www.uniprot.org/uniprot/E41L3_HUMAN E41L3_HUMAN] Critical growth regulator in the pathogenesis of meningiomas.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 19: / Line 19: @@
 </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2he7 ConSurf].
 <div style="clear:both"></div>
-<div style="background-color:#fffaf0;">
-== Publication Abstract from PubMed ==
-Perturbed cell-adhesion mechanisms are crucial for tumor invasion and metastasis. A cell-adhesion protein, Tumor Suppressor in Lung Cancer 1 (TSLC1), is inactivated in a majority of metastatic cancers. DAL-1 (differentially expressed in adenocarcinoma of the lung protein), another tumor suppressor, binds through its FERM domain to the TSLC1 C-terminal, 4.1 glycophorin C-like, cytoplasmic domain. However, the molecular basis for this interaction is unknown. Here, we describe the crystal structure of a complex between the DAL-1 FERM domain and a portion of the TSLC1 cytoplasmic domain. DAL-1 binds to TSLC1 through conserved residues in a well-defined hydrophobic pocket in the DAL-1 FERM domain's structural C-lobe. From the crystal structure, it is apparent that Tyr406 and Thr408 in the TSLC1 cytoplasmic domain form the most important interactions with DAL-1 and this was also confirmed by surface plasmon resonance studies. Our results refute earlier exon deletion experiments that indicated that glycophorin-C interacts with the alpha-lobe of 4.1 FERM domains.
-Structural basis of tumor suppressor in lung cancer 1 (TSLC1) binding to differentially expressed in adenocarcinoma of the lung (DAL-1/4.1B).,Busam RD, Thorsell AG, Flores A, Hammarstrom M, Persson C, Obrink B, Hallberg BM J Biol Chem. 2010 Dec 3. PMID:21131357<ref>PMID:21131357</ref>
-From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-</div>
-<div class="pdbe-citations 2he7" style="background-color:#fffaf0;"></div>
-== References ==
-<references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Arrowsmith, C]]
+[[Category: Arrowsmith C]]
-[[Category: Berglund, H]]
+[[Category: Berglund H]]
-[[Category: Busam, R D]]
+[[Category: Busam RD]]
-[[Category: Collins, R]]
+[[Category: Collins R]]
-[[Category: Edwards, A]]
+[[Category: Edwards A]]
-[[Category: Ehn, M]]
+[[Category: Ehn M]]
-[[Category: Flodin, S]]
+[[Category: Flodin S]]
-[[Category: Flores, A]]
+[[Category: Flores A]]
-[[Category: Graslund, S]]
+[[Category: Graslund S]]
-[[Category: Hallberg, B M]]
+[[Category: Hallberg BM]]
-[[Category: Hammarstrom, M]]
+[[Category: Hammarstrom M]]
-[[Category: Hogbom, M]]
+[[Category: Hogbom M]]
-[[Category: Johansson, I]]
+[[Category: Johansson I]]
-[[Category: Karlberg, T]]
+[[Category: Karlberg T]]
-[[Category: Kotenyova, T]]
+[[Category: Kotenyova T]]
-[[Category: Nilsson-ehle, P]]
+[[Category: Nilsson-ehle P]]
-[[Category: Nilvebrandt, J]]
+[[Category: Nilvebrandt J]]
-[[Category: Norberg, P]]
+[[Category: Norberg P]]
-[[Category: Nordlund, P]]
+[[Category: Nordlund P]]
-[[Category: Nyman, T]]
+[[Category: Nyman T]]
-[[Category: Ogg, D]]
+[[Category: Ogg D]]
-[[Category: Persson, C]]
+[[Category: Persson C]]
-[[Category: Structural genomic]]
+[[Category: Sagemark J]]
-[[Category: Sagemark, J]]
+[[Category: Schiavone LH]]
-[[Category: Schiavone, L H]]
+[[Category: Stenmark P]]
-[[Category: Stenmark, P]]
+[[Category: Sundstrom M]]
-[[Category: Sundstrom, M]]
+[[Category: Thorsell AG]]
-[[Category: Thorsell, A G]]
+[[Category: Uppenberg J]]
-[[Category: Uppenberg, J]]
+[[Category: Van den berg S]]
-[[Category: Weigelt, J]]
+[[Category: Weigelt J]]
-[[Category: Berg, S Van den]]
-[[Category: Cell adhesion]]
-[[Category: Dal-1]]
-[[Category: Epb41l3a]]
-[[Category: Ferm domain]]
-[[Category: Sgc]]