7dm4: Difference between revisions

<StructureSection load='7dm4' size='340' side='right'caption='[[7dm4]]' scene=''>

<table><tr><td colspan='2'>[[7dm4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DM4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DM4 FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dm4 OCA], [https://pdbe.org/7dm4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dm4 RCSB], [https://www.ebi.ac.uk/pdbsum/7dm4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dm4 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/ARI4B_HUMAN ARI4B_HUMAN] Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity).[UniProtKB:A2CG63]<ref>PMID:12724404</ref>  

[[Category: Homo sapiens]]

[[Category: Feng Y]]

[[Category: Gong W]]

[[Category: Hu W]]

[[Category: Perrett S]]

[[Category: Ren J]]

[[Category: Yao H]]