2em6: Difference between revisions
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==Solution structure of the C2H2 type zinc finger (region 199-231) of human Zinc finger protein 224== | ==Solution structure of the C2H2 type zinc finger (region 199-231) of human Zinc finger protein 224== | ||
<StructureSection load='2em6' size='340' side='right'caption='[[2em6 | <StructureSection load='2em6' size='340' side='right'caption='[[2em6]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2em6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2em6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EM6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EM6 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2em6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2em6 OCA], [https://pdbe.org/2em6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2em6 RCSB], [https://www.ebi.ac.uk/pdbsum/2em6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2em6 ProSAT], [https://www.topsan.org/Proteins/RSGI/2em6 TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2em6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2em6 OCA], [https://pdbe.org/2em6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2em6 RCSB], [https://www.ebi.ac.uk/pdbsum/2em6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2em6 ProSAT], [https://www.topsan.org/Proteins/RSGI/2em6 TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/ZN224_HUMAN ZN224_HUMAN] May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.<ref>PMID:20587513</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Abe | [[Category: Abe H]] | ||
[[Category: Kigawa | [[Category: Kigawa T]] | ||
[[Category: Kobayashi | [[Category: Kobayashi N]] | ||
[[Category: Koshiba | [[Category: Koshiba S]] | ||
[[Category: Li | [[Category: Li H]] | ||
[[Category: Saito K]] | |||
[[Category: Saito | [[Category: Sato M]] | ||
[[Category: Sato | [[Category: Tochio N]] | ||
[[Category: Tochio | [[Category: Tomizawa T]] | ||
[[Category: Tomizawa | [[Category: Yokoyama S]] | ||
[[Category: Yokoyama | |||
Latest revision as of 21:52, 29 May 2024
Solution structure of the C2H2 type zinc finger (region 199-231) of human Zinc finger protein 224Solution structure of the C2H2 type zinc finger (region 199-231) of human Zinc finger protein 224
Structural highlights
FunctionZN224_HUMAN May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.[1] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. References
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