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==Solution structure of the CENP-B N-terminal DNA-binding domain of fruit fly distal antenna CG11849-PA== | ==Solution structure of the CENP-B N-terminal DNA-binding domain of fruit fly distal antenna CG11849-PA== | ||
<StructureSection load='2elh' size='340' side='right'caption='[[2elh | <StructureSection load='2elh' size='340' side='right'caption='[[2elh]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2elh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2elh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ELH FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2elh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2elh OCA], [https://pdbe.org/2elh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2elh RCSB], [https://www.ebi.ac.uk/pdbsum/2elh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2elh ProSAT], [https://www.topsan.org/Proteins/RSGI/2elh TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2elh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2elh OCA], [https://pdbe.org/2elh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2elh RCSB], [https://www.ebi.ac.uk/pdbsum/2elh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2elh ProSAT], [https://www.topsan.org/Proteins/RSGI/2elh TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/DAN_DROME DAN_DROME] Probable transcription factor with a role in the retinal determination (RD) network. Regulates ato expression and is required for normal R8 induction and differentiation. Danr appears to repress Dan expression, but Dan is required for Danr expression anterior to the morphogenetic furrow (MF). Dan and Danr lie downstream of so and require dac function for highest levels of expression. Contributes to differentiation of antenna-specific characteristics; effector gene that acts downstream of homothorax (hth), Distal-less (Dll), cut (ct) and spineless (ss) genes to control differentiation of distal antennal structures.<ref>PMID:12571108</ref> <ref>PMID:17493605</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Drosophila melanogaster]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Harada | [[Category: Harada T]] | ||
[[Category: Kigawa | [[Category: Kigawa T]] | ||
[[Category: Koshiba | [[Category: Koshiba S]] | ||
[[Category: Tanaka A]] | |||
[[Category: Tanaka | [[Category: Tochio N]] | ||
[[Category: Tochio | [[Category: Umehara T]] | ||
[[Category: Umehara | [[Category: Watanabe S]] | ||
[[Category: Watanabe | [[Category: Yokoyama S]] | ||
[[Category: Yokoyama | |||
Latest revision as of 21:51, 29 May 2024
Solution structure of the CENP-B N-terminal DNA-binding domain of fruit fly distal antenna CG11849-PASolution structure of the CENP-B N-terminal DNA-binding domain of fruit fly distal antenna CG11849-PA
Structural highlights
FunctionDAN_DROME Probable transcription factor with a role in the retinal determination (RD) network. Regulates ato expression and is required for normal R8 induction and differentiation. Danr appears to repress Dan expression, but Dan is required for Danr expression anterior to the morphogenetic furrow (MF). Dan and Danr lie downstream of so and require dac function for highest levels of expression. Contributes to differentiation of antenna-specific characteristics; effector gene that acts downstream of homothorax (hth), Distal-less (Dll), cut (ct) and spineless (ss) genes to control differentiation of distal antennal structures.[1] [2] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. References
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