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==Allosteric modulator LY3154207 binding to dopamine-bound dopamine receptor 1 in complex with miniGs protein== | |||
<StructureSection load='7ljd' size='340' side='right'caption='[[7ljd]], [[Resolution|resolution]] 3.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7ljd]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Lama_glama Lama glama] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LJD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LJD FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=G4C:2-[2,6-bis(chloranyl)phenyl]-1-[(1~{S},3~{R})-3-(hydroxymethyl)-1-methyl-5-(3-methyl-3-oxidanyl-butyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]ethanone'>G4C</scene>, <scene name='pdbligand=LDP:L-DOPAMINE'>LDP</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ljd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ljd OCA], [https://pdbe.org/7ljd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ljd RCSB], [https://www.ebi.ac.uk/pdbsum/7ljd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ljd ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DRD1_HUMAN DRD1_HUMAN] Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. | |||
==See Also== | |||
*[[Dopamine receptor 3D structures|Dopamine receptor 3D structures]] | |||
*[[Transducin 3D structures|Transducin 3D structures]] | |||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Bos taurus]] | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Huang | [[Category: Lama glama]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Rattus norvegicus]] | ||
[[Category: Krumm | [[Category: Cheng X]] | ||
[[Category: | [[Category: Guo J]] | ||
[[Category: | [[Category: Huang X-P]] | ||
[[Category: Wang | [[Category: Jiang H]] | ||
[[Category: | [[Category: Jiang Y]] | ||
[[Category: | [[Category: Krumm B]] | ||
[[Category: | [[Category: Liu Y]] | ||
[[Category: | [[Category: Melcher K]] | ||
[[Category: | [[Category: Roth BL]] | ||
[[Category: | [[Category: Wang L]] | ||
[[Category: | [[Category: Wang Y]] | ||
[[Category: | [[Category: Xu HE]] | ||
[[Category: Yi W]] | |||
[[Category: Zhang C]] | |||
[[Category: Zhang H]] | |||
[[Category: Zhang Y]] | |||
[[Category: Zhou XE]] | |||
[[Category: Zhuang Y]] | |||
Latest revision as of 14:33, 30 October 2024
Allosteric modulator LY3154207 binding to dopamine-bound dopamine receptor 1 in complex with miniGs proteinAllosteric modulator LY3154207 binding to dopamine-bound dopamine receptor 1 in complex with miniGs protein
Structural highlights
FunctionDRD1_HUMAN Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. See Also |
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