7e14: Difference between revisions
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New page: '''Unreleased structure''' The entry 7e14 is ON HOLD Authors: Cong, Z.T., Chen, L.N., Ma, H.L., Yang, D.H., Xu, H.E., Zhang, Y., Wang, M.W. Description: Compound2_GLP-1R_OWL833_Gs comp... |
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==Compound2_GLP-1R_OWL833_Gs complex structure== | |||
<StructureSection load='7e14' size='340' side='right'caption='[[7e14]], [[Resolution|resolution]] 2.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7e14]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7E14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7E14 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=HNO:N-tert-butyl-6,7-bis(chloranyl)quinoxalin-2-amine'>HNO</scene>, <scene name='pdbligand=V6G:3-[(1S,2S)-1-(5-[(4S)-2,2-dimethyloxan-4-yl]-2-{(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carbonyl}-1H-indol-1-yl)-2-methylcyclopropyl]-1,2,4-oxadiazol-5(4H)-one'>V6G</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e14 OCA], [https://pdbe.org/7e14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e14 RCSB], [https://www.ebi.ac.uk/pdbsum/7e14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e14 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GBB1_HUMAN GBB1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<ref>PMID:18611381</ref> | |||
==See Also== | |||
*[[Glucagon-like peptide receptor 3D structures|Glucagon-like peptide receptor 3D structures]] | |||
*[[Transducin 3D structures|Transducin 3D structures]] | |||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Bos taurus]] | ||
[[Category: Ma | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Rattus norvegicus]] | ||
[[Category: Synthetic construct]] | |||
[[Category: Chen LN]] | |||
[[Category: Cong ZT]] | |||
[[Category: Ma HL]] | |||
[[Category: Wang MW]] | |||
[[Category: Xu HE]] | |||
[[Category: Yang DH]] | |||
[[Category: Zhang Y]] | |||
Latest revision as of 13:54, 27 March 2024
Compound2_GLP-1R_OWL833_Gs complex structureCompound2_GLP-1R_OWL833_Gs complex structure
Structural highlights
FunctionGBB1_HUMAN Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.[1] See AlsoReferences
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