Regulatory protein E2: Difference between revisions
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<StructureSection load='2ayg' size='340' side='right' caption='Human papillomavirus 6a regulatory protein E2 complex with DNA (PDB code | <StructureSection load='2ayg' size='340' side='right' caption='Human papillomavirus 6a regulatory protein E2 complex with DNA (PDB code [[2ayg]])' scene='87/873776/Cv/2'> | ||
== Function == | ==Function== | ||
'''Regulatory protein E2''' (RPE2) is a human papillomavirus (HPV) protein which is required for its replication. RPE2 targets the helicase '''Replication protein E1''' (RPE1) to the origin of replication (ori). The HPV ori contains one RPE1 binding site and 2 RPE2 binding sites<ref>PMID:11504556</ref>. RPE2 is found also in bovine papillomavirus (BPV). | |||
== Disease == | == Disease == | ||
RPE2 induces apoptosis of its host cells<ref>PMID:26906543</ref>. | RPE2 induces apoptosis of its host cells<ref>PMID:26906543</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
<scene name='87/873776/Cv/3'>The complex between HPV6a DBD and 18-bp DNA</scene> (PDB code [[2ayg]]) shows the binding of 2 recognition helices of the dimer to 2 successive major grooves of the target DNA making numerous contacts to the DNA backbone phosphate atoms and to its bases<ref>PMID:16914454</ref>. | |||
</StructureSection> | </StructureSection> | ||
==3D structures of regulatory protein E2== | ==3D structures of regulatory protein E2== | ||
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[[3mi7]] - RPE2 DBD (mutant)<br /> | [[3mi7]] - RPE2 DBD (mutant)<br /> | ||
[[1r8p]], [[1zzf]] - RPE2 DBD - NMR<br /> | [[1r8p]], [[1zzf]] - RPE2 DBD - NMR<br /> | ||
[[1tue]] - RPE2 TAD + | [[1tue]] - RPE2 TAD + RPE1 - HPV18<br /> | ||
[[1qqh]] - RPE2 TAD<br /> | [[1qqh]] - RPE2 TAD<br /> | ||
[[1f9f]] - RPE2 DBD<br /> | [[1f9f]] - RPE2 DBD<br /> | ||