1zuc: Difference between revisions
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<StructureSection load='1zuc' size='340' side='right'caption='[[1zuc]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='1zuc' size='340' side='right'caption='[[1zuc]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1zuc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1zuc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZUC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZUC FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=T98:5-(4,4-DIMETHYL-2-THIOXO-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-6-YL)-1-METHYL-1H-PYRROLE-2-CARBONITRILE'>T98</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=T98:5-(4,4-DIMETHYL-2-THIOXO-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-6-YL)-1-METHYL-1H-PYRROLE-2-CARBONITRILE'>T98</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zuc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zuc OCA], [https://pdbe.org/1zuc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zuc RCSB], [https://www.ebi.ac.uk/pdbsum/1zuc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zuc ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zuc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zuc OCA], [https://pdbe.org/1zuc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zuc RCSB], [https://www.ebi.ac.uk/pdbsum/1zuc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zuc ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/PRGR_HUMAN PRGR_HUMAN] The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref> Isoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Appavu | [[Category: Appavu C]] | ||
[[Category: Berrodin | [[Category: Berrodin T]] | ||
[[Category: Chippari | [[Category: Chippari S]] | ||
[[Category: Chopra | [[Category: Chopra R]] | ||
[[Category: Cohen | [[Category: Cohen J]] | ||
[[Category: Fensome | [[Category: Fensome A]] | ||
[[Category: Li | [[Category: Li S]] | ||
[[Category: Lyttle | [[Category: Lyttle CR]] | ||
[[Category: Olland | [[Category: Olland AM]] | ||
[[Category: Unwalla | [[Category: Unwalla RJ]] | ||
[[Category: Wilhem | [[Category: Wilhem J]] | ||
[[Category: Winneker | [[Category: Winneker RC]] | ||
[[Category: Wrobel | [[Category: Wrobel J]] | ||
[[Category: Zhang | [[Category: Zhang P]] | ||
[[Category: Zhang | [[Category: Zhang Z]] | ||
[[Category: Zhu | [[Category: Zhu Y]] | ||