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| ==PDZ2 from PTP-BL in complex with the C-terminal ligand from the APC protein== | | ==PDZ2 from PTP-BL in complex with the C-terminal ligand from the APC protein== |
| <StructureSection load='1vj6' size='340' side='right'caption='[[1vj6]], [[NMR_Ensembles_of_Models | 35 NMR models]]' scene=''> | | <StructureSection load='1vj6' size='340' side='right'caption='[[1vj6]]' scene=''> |
| == Structural highlights == | | == Structural highlights == |
| <table><tr><td colspan='2'>[[1vj6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VJ6 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1VJ6 FirstGlance]. <br> | | <table><tr><td colspan='2'>[[1vj6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VJ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VJ6 FirstGlance]. <br> |
| </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1gm1|1gm1]], [[1ozi|1ozi]]</div></td></tr> | | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTP-BL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
| | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vj6 OCA], [https://pdbe.org/1vj6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vj6 RCSB], [https://www.ebi.ac.uk/pdbsum/1vj6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vj6 ProSAT]</span></td></tr> |
| <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
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| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1vj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vj6 OCA], [http://pdbe.org/1vj6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vj6 RCSB], [http://www.ebi.ac.uk/pdbsum/1vj6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1vj6 ProSAT]</span></td></tr> | |
| </table> | | </table> |
| == Function == | | == Function == |
| [[http://www.uniprot.org/uniprot/PTN13_MOUSE PTN13_MOUSE]] Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling. [[http://www.uniprot.org/uniprot/APC_MOUSE APC_MOUSE]] Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration (By similarity). Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization (By similarity).<ref>PMID:19893577</ref> | | [https://www.uniprot.org/uniprot/PTN13_MOUSE PTN13_MOUSE] Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling. |
| == Evolutionary Conservation == | | == Evolutionary Conservation == |
| [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
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| </StructureSection> | | </StructureSection> |
| [[Category: Large Structures]] | | [[Category: Large Structures]] |
| [[Category: Lk3 transgenic mice]] | | [[Category: Mus musculus]] |
| [[Category: Protein-tyrosine-phosphatase]]
| | [[Category: Vuister GW]] |
| [[Category: Vuister, G W]] | | [[Category: Walma T]] |
| [[Category: Walma, T]] | |
| [[Category: Apc]]
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| [[Category: C-terminus]]
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| [[Category: Complex]]
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| [[Category: Hydrolase-signaling protein complex]]
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| [[Category: Pdz]]
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| [[Category: Protein-protein interaction]]
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| [[Category: Ptp-bl]]
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