1de1: Difference between revisions

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==NMR STRUCTURES OF OXIDIZED BACTERIOPHAGE T4 GLUTAREDOXIN==
The line below this paragraph, containing "STRUCTURE_1de1", creates the "Structure Box" on the page.
<StructureSection load='1de1' size='340' side='right'caption='[[1de1]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1de1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DE1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DE1 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1de1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1de1 OCA], [https://pdbe.org/1de1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1de1 RCSB], [https://www.ebi.ac.uk/pdbsum/1de1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1de1 ProSAT]</span></td></tr>
{{STRUCTURE_1de1|  PDB=1de1  |  SCENE= }}
</table>
 
== Function ==
'''NMR STRUCTURES OF OXIDIZED BACTERIOPHAGE T4 GLUTAREDOXIN'''
[https://www.uniprot.org/uniprot/GLRX_BPT4 GLRX_BPT4] Serves as a reducing agent for the phage-induced ribonucleotide reductase, but not for the bacterial ones. This specificity may be the result of sequence differences around the redox-active disulfide bond. The oxidized form accepts electrons from bacterial glutathione and will, in turn, reduce other small disulfides. Can also be reduced by NADPH and by bacterial thioredoxin reductase.<ref>PMID:8440680</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==About this Structure==
Check<jmol>
1DE1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DE1 OCA].  
  <jmolCheckbox>
 
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/de/1de1_consurf.spt"</scriptWhenChecked>
==Reference==
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
Solution structures of reduced and oxidized bacteriophage T4 glutaredoxin., Wang Y, Amegbey G, Wishart DS, J Biomol NMR. 2004 May;29(1):85-90. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15017142 15017142]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Enterobacteria phage t4]]
  </jmolCheckbox>
[[Category: Single protein]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1de1 ConSurf].
[[Category: Amegbey, G.]]
<div style="clear:both"></div>
[[Category: Wang, Y.]]
== References ==
[[Category: Wishart, D S.]]
<references/>
[[Category: Glutaredoxin]]
__TOC__
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:44:49 2008''
</StructureSection>
[[Category: Escherichia virus T4]]
[[Category: Large Structures]]
[[Category: Amegbey G]]
[[Category: Wang Y]]
[[Category: Wishart DS]]

Latest revision as of 12:49, 20 March 2024

NMR STRUCTURES OF OXIDIZED BACTERIOPHAGE T4 GLUTAREDOXINNMR STRUCTURES OF OXIDIZED BACTERIOPHAGE T4 GLUTAREDOXIN

Structural highlights

1de1 is a 1 chain structure with sequence from Escherichia virus T4. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GLRX_BPT4 Serves as a reducing agent for the phage-induced ribonucleotide reductase, but not for the bacterial ones. This specificity may be the result of sequence differences around the redox-active disulfide bond. The oxidized form accepts electrons from bacterial glutathione and will, in turn, reduce other small disulfides. Can also be reduced by NADPH and by bacterial thioredoxin reductase.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Nikkola M, Gleason FK, Eklund H. Reduction of mutant phage T4 glutaredoxins by Escherichia coli thioredoxin reductase. J Biol Chem. 1993 Feb 25;268(6):3845-9. PMID:8440680
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