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<StructureSection load='7jsv' size='340' side='right'caption='[[7jsv]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
<StructureSection load='7jsv' size='340' side='right'caption='[[7jsv]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7jsv]] is a 41 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JSV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7JSV FirstGlance]. <br>
<table><tr><td colspan='2'>[[7jsv]] is a 41 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JSV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LHG:1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE'>LHG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7jsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jsv OCA], [http://pdbe.org/7jsv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7jsv RCSB], [http://www.ebi.ac.uk/pdbsum/7jsv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7jsv ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LHG:1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE'>LHG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jsv OCA], [https://pdbe.org/7jsv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jsv RCSB], [https://www.ebi.ac.uk/pdbsum/7jsv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jsv ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/A6TIG0_KLEP7 A6TIG0_KLEP7]
Conjugative pili are important in mediating bacterial conjugation and horizontal gene transfer. Since plasmid transfer can include antibiotic-resistance genes, conjugation is an important mechanism in the spread of antibiotic resistance. Filamentous bacteriophages have been shown to exist in two different structural classes: those with a 5-fold rotational symmetry and those with a one-start helix with approximately 5 subunits per turn. Structures for the F and the F-like pED208 conjugation pilus have shown that they have 5-fold rotational symmetry. Here, we report the cryoelectron-microscopic structure of conjugative pili from carbapenem-resistant Klebsiella pneumoniae, encoded on the IncFIIK pKpQIL plasmid, at 3.9 A resolution and show that it has a one-start helix. These results establish that conjugation pili can exist in at least two structural classes, consistent with other results showing that relatively small perturbations are needed to change the helical symmetry of polymers.
 
Cryoelectron-Microscopic Structure of the pKpQIL Conjugative Pili from Carbapenem-Resistant Klebsiella pneumoniae.,Zheng W, Pena A, Low WW, Wong JLC, Frankel G, Egelman EH Structure. 2020 Sep 8. pii: S0969-2126(20)30292-6. doi:, 10.1016/j.str.2020.08.010. PMID:32916103<ref>PMID:32916103</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7jsv" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Pilin 3D structures|Pilin 3D structures]]
*[[Pilin 3D structures|Pilin 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Klebsiella pneumoniae]]
[[Category: Klebsiella pneumoniae]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Egelman, E H]]
[[Category: Egelman EH]]
[[Category: Frankel, G]]
[[Category: Frankel G]]
[[Category: Pena, A]]
[[Category: Pena A]]
[[Category: Zheng, W]]
[[Category: Zheng W]]
[[Category: Conjugation pili]]
[[Category: Helical reconstruction]]
[[Category: Protein fibril]]

Latest revision as of 17:53, 6 March 2024

Cryo-EM structure of conjugative pili from carbapenem-resistant Klebsiella pneumoniaeCryo-EM structure of conjugative pili from carbapenem-resistant Klebsiella pneumoniae

Structural highlights

7jsv is a 41 chain structure with sequence from Klebsiella pneumoniae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 3.9Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

A6TIG0_KLEP7

See Also

7jsv, resolution 3.90Å

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