6tql: Difference between revisions

<table><tr><td colspan='2'>[[6tql]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TQL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TQL FirstGlance]. <br>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tql OCA], [http://pdbe.org/6tql PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tql RCSB], [http://www.ebi.ac.uk/pdbsum/6tql PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tql ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/UROM_HUMAN UROM_HUMAN]] UMOD-related autosomal dominant tubulointerstitial kidney disease. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  

[[http://www.uniprot.org/uniprot/UROM_HUMAN UROM_HUMAN]] Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability (Probable). May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF (PubMed:3498215). Facilitates neutrophil migration across renal epithelia (PubMed:20798515).<ref>PMID:20798515</ref> <ref>PMID:3498215</ref>  In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals.[UniProtKB:Q91X17]