Stimulator of interferon genes: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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 <StructureSection load='' size='350' side='right' caption='Structure of human STING CTD complex with c-GMP-AMP (PDB entry [[4loh]])' scene='57/573101/Cv/1'>
-'''Stimulator of interferon genes''' (STING) induces production of type I interferon when cells are infected by viruses, mycobacteria and intracellular parasites.  STING recognizes and binds cyclic-di-GMP produced by bacteria and cyclic-GMP AMP (cGAMP) produced by viruses.  The C-terminal domain (CTD) (residues 139-379 in human) of STING binds cyclic-di-GMP.  STING is a facilitator of innate immune signaling<ref>PMID:26980676</ref>.
+== Function ==
+'''Stimulator of interferon genes protein''' or '''transmembrane protein 173''' (STING) is an ER-associated membrane protein.  STING signals immune responses in human and other animals. STING is activated by cyclic GMP-AMP produced by [[Cyclic GMP-AMP synthase]] whose activity is triggered by infections of DNA-containing pathogens<ref>PMID:30842659</ref>. A PLPLRT/SD conserved motif at the STING C-terminal plays a critical role in turning on the immune system to fight against viral infections<ref>PMID:31118511</ref>.
+== Disease ==
+STING mutations are associated with autoimmune diseases<ref>PMID:26235147</ref>.
 == Structural highlights ==
-The <scene name='57/573101/Cv/4'>cyclic dinucleotide binds the STING in a U-shaped cleft between the 2 monomers</scene><ref>PMID:23910378</ref>. Water molecules are shown as red spheres.
+The 3D structure of the complex between human STING and cyclic GMP-AMP shows the dinucleotide bound by the symmetric dimer of STING. The <scene name='57/573101/Cv/5'>U-shaped cleft</scene> between the 2 subunits makes numerous interactions with the U-shaped ligand. <scene name='57/573101/Cv/4'>GMP-AMP binding site</scene> (water molecules are shown as red spheres). A <scene name='57/573101/Cv/6'>Tyr residue from each monomer stacks</scene> against each of the purine moieties while an <scene name='57/573101/Cv/7'>Arg residue from each monomer forms hydrogen bonds to the dinucleotide</scene> <ref>PMID:23910378</ref>.
+==3D structures of stimulator of interferon genes protein==
+[[Stimulator of interferon genes protein 3D structures]]
 </StructureSection>
-==3D structures of STING==
-(Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*Stimulator of interferon genes
-Domain: CTD 139-379
-**[[6nt5]] – hSTING – human - Cryo EM  <br />
-**[[4ef5]], [[4f5w]], [[4f9e]] – hSTING CTD<br />
-**[[4f5e]] – hSTING CTD (mutant)   <br />
-**[[4jc5]], [[4kc0]] – mSTING CTD - mouse  <br />
-**[[6nt6]] – cSTING – chicken – Cryo EM  <br />
-**[[5cfo]], [[5cfr]] – saSTING CTD – sea anemone  <br />
-*Stimulator of interferon genes complex with ligand
-**[[4ef4]], [[4f5y]], [[4f9g]], [[4emt]] – hSTING CTD + c-di-GMP <br />
-**[[4f5d]] – hSTING CTD (mutant) + c-di-GMP  <br />
-**[[4ksy]] – hSTING CTD + c-GAMP <br />
-**[[5bqx]] – hSTING CTD + c-GMP  <br />
-**[[4loh]], [[4loi]] – hSTING CTD + c-di-GMP derivative<br />
-**[[6cff]] – hSTING CTD + c-di-AMP  <br />
-**[[6dnk]] – hSTING CTD + c-GMP-AMP  <br />
-**[[4qxo]], [[4qxp]], [[4qxq]], [[4qxr]] – hSTING CTD + chemptherapeutic agent DMXAA<br />
-**[[6dxl]], [[6dxg]] – hSTING CTD (mutant) + imidazole derivative  <br />
-**[[6a06]] – pSTING CTD + c-GAMP - pig<br />
-**[[6a05]] – pSTING CTD + purine derivative<br />
-**[[6a04]] – pSTING CTD + c-di-GMP<br />
-**[[6a03]], [[6iyf]] – pSTING CTD + c-di-AMP<br />
-**[[5jej]] – hSTING residues 342-379 + IRF-3  <br />
-**[[4kby]] – mSTING CTD + c-di-GMP  <br />
-**[[4loj]], [[4lok]] – mSTING CTD + c-di-GMP derivative<br />
-**[[4yp1]] – mSTING CTD + c-di-AMP derivative<br />
-**[[4lol]] – mSTING CTD + chemptherapeutic agent DMXAA<br />
-**[[4kby]] – mSTING CTD + c-di-GMP  <br />
-**[[6nt7]], [[6nt8]] – cSTING + GMP-AMP – Cryo EM <br />
-**[[6nt9]] – cSTING + TBK1 – Cryo EM <br />
-**[[5cfl]] – saSTING CTD + c-di-GMP  <br />
-**[[5cfp]] – saSTING CTD (mutant) + c-di-GMP  <br />
-**[[5cfq]] – saSTING CTD + c-AMP-GMP  <br />
-**[[5cfm]] – saSTING CTD + c-GMP  <br />
-**[[5cfn]] – saSTING CTD + c-di-AMP  <br />
-}}
 == References ==
 <references/>
 [[Category:Topic Page]]